Gene Page: RANBP2

Summary
GeneID  5903
Symbol  RANBP2
Synonyms  NUP358|TRP1|TRP2
Description  RAN binding protein 2
See related  HGNC:9848|MIM:601181|Ensembl:ENSG00000153201|HPRD:03111|
Locus tag  -
Gene type  protein-coding
Map location  2q12.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.024 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TEX100.950.92
KLHL70.950.92
DDX50.950.88
HSF20.950.92
XRN20.940.89
CEP570.940.90
NOL110.940.91
POLR2B0.940.91
ZNF1950.940.89
DHX90.940.87
Top 10 negatively co-expressed genes
HLA-F-0.75-0.82
AIFM3-0.73-0.81
MT-CO2-0.72-0.87
AF347015.33-0.72-0.87
AF347015.31-0.72-0.85
AF347015.27-0.72-0.86
MT-CYB-0.72-0.88
HEPN1-0.71-0.81
TSC22D4-0.70-0.81
AF347015.8-0.70-0.87
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003755peptidyl-prolyl cis-trans isomerase activityIEA-
GO:0005515protein bindingIPI16332688 |17353931 |18394993 
GO:0016853isomerase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008536Ran GTPase bindingTAS7603572 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006457protein foldingIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006606protein import into nucleusTAS7603572 
GO:0051028mRNA transportIEA-
GO:0015031protein transportIEA-
GO:0046907intracellular transportIEA-
GO:0065002intracellular protein transmembrane transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12228227 
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005643nuclear poreTAS7603572 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
IPO5DKFZp686O1576 | FLJ43041 | IMB3 | KPNB3 | MGC2068 | RANBP5importin 5-HPRD9114010 
KPNA1IPOA5 | NPI-1 | RCH2 | SRP1karyopherin alpha 1 (importin alpha 5)Reconstituted ComplexBioGRID10473610 
KPNB1IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97karyopherin (importin) beta 1-HPRD,BioGRID10473610 
NUP62DKFZp547L134 | FLJ20822 | FLJ43869 | IBSN | MGC841 | SNDI | p62nucleoporin 62kDa-HPRD11266456 
OPN1LWCBBM | CBP | RCPopsin 1 (cone pigments), long-wave-sensitive-HPRD,BioGRID8857542 
OPN1MWCBBM | CBD | GCP | MGC176615 | OPN1MW1opsin 1 (cone pigments), medium-wave-sensitive-HPRD,BioGRID8857542 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene family-HPRD,BioGRID10318915 
RANGAP1Fug1 | KIAA1835 | MGC20266 | SDRan GTPase activating protein 1-HPRD9019411 |11854305 
|12192048 
SAE1AOS1 | FLJ3091 | HSPC140 | SUA1SUMO1 activating enzyme subunit 1Biochemical ActivityBioGRID11792325 
SP100DKFZp686E07254 | FLJ00340 | FLJ34579SP100 nuclear antigenBiochemical ActivityBioGRID18691969 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)Reconstituted ComplexBioGRID12192048 
SUMO-1 interacts with RanBP2.BIND15608651 
TNPO1IPO2 | KPNB2 | MIP | MIP1 | TRNtransportin 1-HPRD9144189 
UBA2ARX | FLJ13058 | HRIHFB2115 | SAE2ubiquitin-like modifier activating enzyme 2Biochemical ActivityBioGRID11792325 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Ubc9 interacts with RanBP2.BIND15608651 
RanBP2 interacts with Ubc9.BIND15378033 
-HPRD,BioGRID12192048 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD10601307 
XPOTXPO3exportin, tRNA (nuclear export receptor for tRNAs)-HPRD12138183 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
PID_RANBP2_PATHWAY 1111All SZGR genes in this pathway
REACTOME_METABOLISM_OF_NON_CODING_RNA 4929All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 6645All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 5434All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 3321All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_GLUCOSE_TRANSPORT 3829All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
REACTOME_INFLUENZA_LIFE_CYCLE 20372All SZGR genes in this pathway
REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY 2719All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS 2719All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 10461All SZGR genes in this pathway
REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS 3321All SZGR genes in this pathway
REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN 2719All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP 2616All SZGR genes in this pathway
DUNNE_TARGETS_OF_AML1_MTG8_FUSION_DN 1917All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN 8871All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
ABRAMSON_INTERACT_WITH_AIRE 4533All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/987007071A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-133378384m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-1372702771A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-5p8198251Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-1533063121Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-196699705m8hsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-199194200m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-2178358411Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-221/2228608661Ahsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-3771751811Ahsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-4483053121A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4961141201Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-9504510m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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