Gene Page: UPF1

Summary
GeneID  5976
Symbol  UPF1
Synonyms  FLJ43809|FLJ46894|HUPF1|KIAA0221|NORF1|RENT1|pNORF1
Description  UPF1 regulator of nonsense transcripts homolog (yeast)
See related  HGNC:9962|MIM:601430|Ensembl:ENSG00000005007|HPRD:03254|
Locus tag  -
Gene type  protein-coding
Map location  19p13.2-p13.11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.5939 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingIEA-
GO:0003682chromatin bindingIDA16488880 
GO:0003723RNA bindingNAS10999600 
GO:0004004ATP-dependent RNA helicase activityIDA12554878 
GO:0005515protein bindingIPI9620853 |11544179 
GO:0005524ATP bindingIEA-
GO:0004386helicase activityNAS9064659 
GO:0016787hydrolase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayNAS10999600 
GO:0006396RNA processingTAS8855285 
GO:0006406mRNA export from nucleusTAS16488880 
GO:0006449regulation of translational terminationIMP9620853 
GO:0006449regulation of translational terminationNAS10999600 
GO:0006281DNA repairIDA16488880 
GO:0006260DNA replicationIMP16488880 
GO:0007049cell cycleIMP16488880 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000785chromatinIDA16488880 
GO:0005737cytoplasmNAS9064659 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedATM phosphorylates hUpf1.BIND15175154 
DCP1AFLJ21691 | HSA275986 | Nbla00360 | SMAD4IP1 | SMIFDCP1 decapping enzyme homolog A (S. cerevisiae)Affinity Capture-WesternBioGRID12417715 
DCP2FLJ33245 | NUDT20DCP2 decapping enzyme homolog (S. cerevisiae)-HPRD,BioGRID12417715 
EXOSC10PM-Scl | PM/Scl-100 | PMSCL | PMSCL2 | RRP6 | Rrp6p | p2 | p3 | p4exosome component 10Affinity Capture-WesternBioGRID14527413 
EXOSC2RRP4 | Rrp4p | hRrp4p | p7exosome component 2Affinity Capture-WesternBioGRID14527413 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4-HPRD,BioGRID14527413 
HIRADGCR1 | TUP1 | TUPLE1HIR histone cell cycle regulation defective homolog A (S. cerevisiae)-HPRD,BioGRID15231747 
LSM8YJR022WLSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID15231747 
PABPC1PAB1 | PABP | PABP1 | PABPC2 | PABPL1poly(A) binding protein, cytoplasmic 1Affinity Capture-MSBioGRID12723973 
PARNDANpoly(A)-specific ribonuclease (deadenylation nuclease)Affinity Capture-WesternBioGRID14527413 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDa-HPRD6200476 
SMG161E3.4 | ATX | KIAA0421 | LIPPI-3-kinase-related kinase SMG-1-HPRD,BioGRID11544179 
hSMG-1 phosphorylates hUpf1.BIND15175154 
SMG5EST1B | FLJ34864 | KIAA1089 | LPTS-RP1 | LPTSRP1 | RP11-54H19.7 | SMG-5Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)-HPRD14636577 
SMG6C17orf31 | EST1A | KIAA0732 | SMG-6Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)UPF1 interacts with SMG6.BIND15721257 
SMG7C1orf16 | EST1C | FLJ23717 | KIAA0250 | SGA56M | SMG-7Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)SMG7 interacts with UPF1.BIND15721257 
STAU1FLJ25010 | STAUstaufen, RNA binding protein, homolog 1 (Drosophila)Upf1 interacts with Stau1.BIND15680326 
UPF2DKFZp434D222 | HUPF2 | KIAA1408 | MGC138834 | MGC138835 | RENT2 | smg-3UPF2 regulator of nonsense transcripts homolog (yeast)Upf1 interacts with Upf2.BIND15680326 
-HPRD,BioGRID11073994 
-HPRD11073994 |12723973 
UPF3AHUPF3A | RENT3A | UPF3UPF3 regulator of nonsense transcripts homolog A (yeast)-HPRD,BioGRID11163187 
UPF3BHUPF3B | MRXS14 | RENT3B | UPF3XUPF3 regulator of nonsense transcripts homolog B (yeast)Upf1 interacts with Upf3X.BIND15680326 
-HPRD,BioGRID12723973 
XRN1DKFZp434P0721 | DKFZp686B22225 | DKFZp686F19113 | FLJ41903 | SEP15'-3' exoribonuclease 1-HPRD,BioGRID14527413 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
FRASOR_TAMOXIFEN_RESPONSE_UP 5136All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_UP 156101All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
CAMPS_COLON_CANCER_COPY_NUMBER_UP 9245All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128114120m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-186567573m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-3703713771Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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