Gene Page: BCL2L2

Summary
GeneID  599
Symbol  BCL2L2
Synonyms  BCL-W|BCLW|KIAA0271
Description  BCL2-like 2
See related  HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|
Locus tag  -
Gene type  protein-coding
Map location  14q11.2-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BCAM0.600.72
PERP0.590.68
ZFP360.590.49
SSH30.550.63
ICAM10.540.58
LASS10.540.61
SLCO4A10.520.57
FOXF10.500.51
APOLD10.490.36
MOBKL2C0.490.56
Top 10 negatively co-expressed genes
AKT3-0.34-0.45
ZNF33B-0.33-0.45
PHF14-0.33-0.52
NLGN1-0.33-0.40
ROBO2-0.32-0.44
EPHA7-0.32-0.44
DOK6-0.32-0.41
ENY2-0.32-0.40
TRDMT1-0.32-0.39
FANCM-0.32-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI15694340 |16697956 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007283spermatogenesisTAS8761287 
GO:0006916anti-apoptosisTAS9500547 
GO:0042981regulation of apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmNAS-
GO:0005739mitochondrionIEA-
GO:0016020membraneIEA-
GO:0031966mitochondrial membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BADBBC2 | BCL2L8BCL2-associated agonist of cell death-HPRD,BioGRID11483855 |12115603 
Bad interacts with Bcl-w.BIND15694340 
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1Affinity Capture-WesternBioGRID10381646 
BAXBCL2L4BCL2-associated X proteinAffinity Capture-WesternBioGRID10381646 
BBC3JFY1 | PUMABCL2 binding component 3Puma interacts with Bcl-w.BIND15694340 
BCL2L11BAM | BIM | BIM-alpha6 | BIM-beta6 | BIM-beta7 | BOD | BimEL | BimLBCL2-like 11 (apoptosis facilitator)Bim interacts with Bcl-w.BIND15694340 
Two-hybridBioGRID9731710 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistProtein-peptideBioGRID15694340 
Bid interacts with Bcl-w.BIND15694340 
BIKBIP1 | BP4 | NBKBCL2-interacting killer (apoptosis-inducing)Affinity Capture-WesternBioGRID10381646 
Bik interacts with Bcl-w.BIND15694340 
BMFFLJ00065Bcl2 modifying factorBmf interacts with Bcl-w. This interaction was modelled on a demonstrated interaction between mouse Bmf and human Bcl-w.BIND15694340 
-HPRD,BioGRID11546872 
HRKDP5 | HARAKIRIharakiri, BCL2 interacting protein (contains only BH3 domain)Hrk interacts with Bcl-w.BIND15694340 
Protein-peptideBioGRID15694340 
PMAIP1APR | NOXAphorbol-12-myristate-13-acetate-induced protein 1Protein-peptideBioGRID15694340 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoformAffinity Capture-Western
Reconstituted Complex		BioGRID12115603 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN 8454All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
GALLUZZI_PREVENT_MITOCHONDIAL_PERMEABILIZATION 2216All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
KREPPEL_CD99_TARGETS_DN 85All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_UP 7149All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
EHLERS_ANEUPLOIDY_UP 4129All SZGR genes in this pathway
MATZUK_EMBRYONIC_GERM_CELL 1916All SZGR genes in this pathway
MATZUK_MALE_REPRODUCTION_SERTOLI 2823All SZGR genes in this pathway
MATZUK_SPERMATOCYTE 7255All SZGR genes in this pathway
MATZUK_SPERMATID_DIFFERENTIATION 3726All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
BEIER_GLIOMA_STEM_CELL_DN 6642All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE 10176All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10190219081Ahsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-103/107136413701Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-122133113371Ahsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-133154415511A,m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-14019541960m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-148/152145014561Ahsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-149135013571A,m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/49713901396m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d15991605m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-214193519411Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-24134813551A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-29137913851Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-3p193819441Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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