Gene Page: ACTB

Summary
GeneID  60
Symbol  ACTB
Synonyms  PS1TP5BP1
Description  actin, beta
See related  HGNC:132|MIM:102630|Ensembl:ENSG00000075624|HPRD:00032|
Locus tag  -
Gene type  protein-coding
Map location  7p15-p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0551 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17342765 
GO:0005524ATP bindingIEA-
GO:0005198structural molecule activityIEA-
GO:0005200structural constituent of cytoskeletonTAS6202424 
GO:0050998nitric-oxide synthase bindingIPI17502619 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007605sensory perception of soundIEA-
GO:0006928cell motionTAS6202424 |16130169 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIEA-
GO:0005856cytoskeletonIEA-
GO:0005856cytoskeletonTAS16130169 
GO:0005625soluble fractionIEA-
GO:0005737cytoplasmTAS16130169 
GO:0035267NuA4 histone acetyltransferase complexIDA10966108 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABRASTARSactin-binding Rho activating protein-HPRD11983702 
ACTBPS1TP5BP1actin, betaAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9209005 |16189514 
Actin interacts with itself to form an F-actin.BIND15361876 
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD8913639 
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1Two-hybridBioGRID16189514 
ARPC1BARC41 | p40-ARC | p41-ARCactin related protein 2/3 complex, subunit 1B, 41kDa-HPRD11533442 |11721045 
C20orf20Eaf7 | FLJ10914 | MRG15BP | MRGBP | URCC4chromosome 20 open reading frame 20-HPRD12963728 
CCT299D8.1 | CCT-beta | CCTB | MGC142074 | MGC142076 | PRO1633 | TCP-1-betachaperonin containing TCP1, subunit 2 (beta)-HPRD,BioGRID10748209|11580269 
CCT5CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilonchaperonin containing TCP1, subunit 5 (epsilon)-HPRD,BioGRID11580269 
CCT8C21orf112 | Cctq | D21S246 | KIAA0002 | PRED71chaperonin containing TCP1, subunit 8 (theta)-HPRD10748209 
CFL1CFLcofilin 1 (non-muscle)Two-hybridBioGRID16189514 
CFL2NEM7cofilin 2 (muscle)Affinity Capture-Western
Two-hybrid		BioGRID16189514 
CIITAC2TA | CIITAIV | MHC2TA | NLRAclass II, major histocompatibility complex, transactivatorBeta-actin interacts with p-MHC2TA.BIND15502823 
CLIC4CLIC4L | DKFZp566G223 | FLJ38640 | H1 | MTCLIC | huH1 | p64H1chloride intracellular channel 4-HPRD11563969 
CPNE1COPN1 | CPN1 | MGC1142copine I-HPRD12522145 
CPNE2COPN2 | CPN2 | DKFZp686E06199 | MGC16924copine II-HPRD12522145 
CPNE4COPN4 | CPN4 | MGC15604copine IV-HPRD12522145 
DNASE1DKFZp686H0155 | DNL1 | DRNI | FLJ38093 | FLJ44902deoxyribonuclease IDNASE1 (DNase I) interacts with ACTB (beta-actin).BIND15711563 
DSTNACTDP | ADF | bA462D18.2destrin (actin depolymerizing factor)Two-hybridBioGRID16189514 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
EMDEDMD | LEMD5 | STAemerin-HPRD12670476 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrin-HPRD7876308 
FLIIFLI | FLIL | Fli1 | MGC39265flightless I homolog (Drosophila)-HPRD9525888 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD10945978 
HNRNPUHNRPU | SAF-A | U21.1heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)ACTB (beta-actin) interacts with HNRPU (hnRNP U).BIND15711563 
IFI66-16 | FAM14C | G1P3 | IFI-6-16 | IFI616interferon, alpha-inducible protein 6Beta-actin interacts with p-G1P3.BIND15502823 
LGALS13GAL13 | PLAC8 | PP13lectin, galactoside-binding, soluble, 13-HPRD15009185 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Co-purificationBioGRID11839798 
NCALDMGC33870 | MGC74858neurocalcin deltaAffinity Capture-WesternBioGRID16189514 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1Far WesternBioGRID11027608 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogene-HPRD11027608 
NCF2FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOXneutrophil cytosolic factor 2Far WesternBioGRID11027608 
NEBLFLJ53769 | LNEBL | MGC119746 | MGC119747 | bA56H7.1nebulette-HPRD10470015 
NRAP-nebulin-related anchoring protein-HPRD9295142 
OSTF1FLJ20559 | OSF | SH3P2 | bA235O14.1osteoclast stimulating factor 1SH3P2 interacts with beta-actin.BIND15135048 
P2RX7MGC20089 | P2X7purinergic receptor P2X, ligand-gated ion channel, 7-HPRD11707406 
PCYT1BCCT-beta | CTBphosphate cytidylyltransferase 1, choline, betaCo-crystal StructureBioGRID11580269 
PFDN1PDF | PFD1prefoldin subunit 1-HPRD11535601 
PFN1-profilin 1-HPRD,BioGRID10411937 
PFN2D3S1319E | PFLprofilin 2-HPRD10600384 
PLD1-phospholipase D1, phosphatidylcholine-specific-HPRD11373276 
PLD2-phospholipase D2-HPRD11373276 
POLR1BFLJ10816 | FLJ21921 | MGC131780 | RPA135 | RPA2 | Rpo1-2polymerase (RNA) I polypeptide B, 128kDaPol I interacts with actin.BIND15558034 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophin-HPRD9739080 
RAB8BFLJ38125RAB8B, member RAS oncogene familyAffinity Capture-WesternBioGRID12639940 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID11027608 
RAC2EN-7 | Gx | HSPC022ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)-HPRD,BioGRID11027608 
RIBIN-rRNA promoter binding proteinActin interacts with rDNA.BIND15558034 
RRN3DKFZp566E104 | MGC104238 | TIFIARRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)TIF-IA interacts with actin.BIND15558034 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID9845365 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Affinity Capture-WesternBioGRID9845365 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1Affinity Capture-WesternBioGRID9845365 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)-HPRD9209005 
SPTBN2GTRAP41 | SCA5spectrin, beta, non-erythrocytic 2Reconstituted ComplexBioGRID11357136 
SSH1FLJ38102 | KIAA1298 | SSH-1slingshot homolog 1 (Drosophila)Reconstituted ComplexBioGRID11832213 
SSH2KIAA1725 | MGC78588 | SSH-2slingshot homolog 2 (Drosophila)Reconstituted ComplexBioGRID11832213 
SYNJ2BPARIP2 | FLJ11271 | FLJ41973 | OMP25synaptojanin 2 binding protein-HPRD11673475 |11696420 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TPM2AMCD1 | DA1 | DA2B | TMSBtropomyosin 2 (beta)-HPRD9108196 
TPM3FLJ41118 | MGC14582 | MGC3261 | MGC72094 | NEM1 | OK/SW-cl.5 | TM-5 | TM3 | TM30 | TM30nm | TPMsk3 | TRK | hscp30tropomyosin 3-HPRD9108196 
XPO6EXP6 | FLJ22519 | KIAA0370 | RANBP20exportin 6-HPRD14592989 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_VIBRIO_CHOLERAE_INFECTION 5632All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 5936All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
WNT_SIGNALING 8971All SZGR genes in this pathway
REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC 2815All SZGR genes in this pathway
REACTOME_PROTEIN_FOLDING 5330All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_DN 2113All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_UP 5534All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
MAYBURD_RESPONSE_TO_L663536_DN 5632All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
CAVARD_LIVER_CANCER_MALIGNANT_VS_BENIGN 3219All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_3 4831All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY 6648All SZGR genes in this pathway
DACOSTA_LOW_DOSE_UV_RESPONSE_VIA_ERCC3_XPCS_DN 96All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
RAHMAN_TP53_TARGETS_PHOSPHORYLATED 2118All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
PETRETTO_CARDIAC_HYPERTROPHY 3426All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_7P22_AMPLICON 3827All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_G1_G2_DN 2518All SZGR genes in this pathway
GNATENKO_PLATELET_SIGNATURE 4828All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
CHEN_LUNG_CANCER_SURVIVAL 2822All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_EXPRESSION 4029All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_DN 2616All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
YAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP 7958All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_4HR 3722All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_DN 5739All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
MODY_HIPPOCAMPUS_NEONATAL 3525All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_DN 1612All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP 4333All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
WHITESIDE_CISPLATIN_RESISTANCE_DN 139All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_UP 7148All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN 9671All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_UP 4731All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE 7750All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM 6647All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
BASSO_HAIRY_CELL_LEUKEMIA_DN 8066All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 181101All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
DORMOY_ELAVL1_TARGETS 1710All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
HUANG_GATA2_TARGETS_DN 7252All SZGR genes in this pathway
STEINER_ERYTHROCYTE_MEMBRANE_GENES 1510All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.14124181Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-1451451521A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-205500506m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-4862722781Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-54453591Ahsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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