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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: ATXN1

Summary

GeneID

6310

Symbol

ATXN1

Synonyms

ATX1|D6S504E|SCA1

Description

ataxin 1

Locus tag

Gene type

protein-coding

Map location

6p23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 15.9635

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

MYLK

0.76

0.82

ACSL6

0.74

0.79

CBX7

0.74

0.80

SUSD5

0.74

0.77

0.73

0.72

FBLN7

0.73

0.66

KCNS3

0.73

0.78

EHD2

0.73

0.82

KLF9

0.72

0.79

BHLHE40

0.72

0.74

Top 10 negatively co-expressed genes

KIAA1949

-0.55

-0.56

TUBB2B

-0.55

-0.62

TRAF4

-0.54

-0.69

BCL7C

-0.54

-0.72

ZNF311

-0.53

-0.59

MARCKSL1

-0.52

-0.56

HN1

-0.52

-0.55

DYNLT1

-0.52

-0.75

PAFAH1B3

-0.52

-0.63

PPP1R14B

-0.52

-0.70

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003723

RNA binding

IEA

GO:0008266

poly(U) binding

IDA

11136710

GO:0008022

protein C-terminus binding

IPI

12757932 |15016912

GO:0016564

transcription repressor activity

IDA

15016912

GO:0034046

poly(rG) binding

IDA

11136710

GO:0042802

identical protein binding

IPI

16713569

GO:0043621

protein self-association

IDA

9097953

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006396

RNA processing

NAS

15615787

GO:0008219

cell death

IEA

GO:0016481

negative regulation of transcription

IDA

15016912

GO:0051168

nuclear export

IDA

15615787

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IDA

7647801

GO:0005654

nucleoplasm

IDA

12757932

GO:0005737

cytoplasm

IDA

7647801

GO:0042272

nuclear RNA export factor complex

IDA

15615787

GO:0016363

nuclear matrix

IDA

17557114

GO:0042405

nuclear inclusion body

IDA

15615787

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANP32A	C15orf1 \| I1PP2A \| LANP \| MAPM \| MGC119787 \| MGC150373 \| PHAP1 \| PHAPI \| PP32	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	-	HPRD,BioGRID	9353121
COIL	CLN80 \| p80-coilin	coilin	-	HPRD,BioGRID	12757932
GAPDH	G3PD \| GAPD \| MGC88685	glyceraldehyde-3-phosphate dehydrogenase	-	HPRD,BioGRID	8872471
PQBP1	MRX55 \| MRXS3 \| MRXS8 \| NPW38 \| RENS1 \| SHS	polyglutamine binding protein 1	-	HPRD,BioGRID	12062018
UBQLN4	A1U \| C1orf6 \| CIP75 \| UBIN	ubiquilin 4	-	HPRD,BioGRID	11001934
USP7	HAUSP \| TEF1	ubiquitin specific peptidase 7 (herpes virus-associated)	-	HPRD,BioGRID	12093161
ZHX1	-	zinc fingers and homeoboxes 1	Two-hybrid	BioGRID	12659632

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP	485	293	All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_UP	74	45	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN	320	184	All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN	241	146	All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP	404	246	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP	418	263	All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP	157	104	All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP	171	112	All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_UP	130	85	All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_DN	91	58	All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN	104	72	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	805	505	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_DN	77	52	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN	229	142	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN	84	63	All SZGR genes in this pathway
ROVERSI_GLIOMA_LOH_REGIONS	44	30	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
SEMBA_FHIT_TARGETS_UP	11	7	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN	584	395	All SZGR genes in this pathway
OZEN_MIR125B1_TARGETS	25	15	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP	424	268	All SZGR genes in this pathway
LU_IL4_SIGNALING	94	56	All SZGR genes in this pathway
MANALO_HYPOXIA_UP	207	145	All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS	191	131	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM	302	191	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	287	208	All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN	434	302	All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP	280	183	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN	101	64	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP	953	554	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP	783	442	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1	528	324	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED	1022	619	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN	220	147	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN	249	165	All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP	425	253	All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_DN	59	39	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP	442	263	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION	130	87	All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED	351	238	All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_UP	80	54	All SZGR genes in this pathway
GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN	56	39	All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP	397	206	All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP	139	93	All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN	88	61	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN	321	200	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN	448	282	All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN	308	187	All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF	222	159	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	3821	3827	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-101	1174	1181	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
				hsa-miR-101	UACAGUACUGUGAUAACUGAAG
				hsa-miR-101	UACAGUACUGUGAUAACUGAAG
				hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-125/351	4097	4104	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
				hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
				hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
				hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-130/301	6929	6936	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-132/212	3723	3729	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	3723	3729	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-137	2662	2668	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-139	60	66	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-141/200a	869	876	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
				hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
				hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-144	5438	5444	m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
				hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
				hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
				hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
				hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-148/152	677	684	1A,m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-17-5p/20/93.mr/106/519.d	4147	4153	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-18	6808	6815	1A,m8	hsa-miR-18a	UAAGGUGCAUCUAGUGCAGAUA
miR-18	6808	6815	1A,m8	hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
miR-181	5157	5163	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
				hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	4331	4338	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-188	5604	5610	m8	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-19	1529	1536	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
				hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
				hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
				hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429	79	85	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-218	4847	4853	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-219	3617	3623	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-221/222	1626	1633	1A,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1626	1633	1A,m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-23	1325	1332	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1325	1332	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/367	4240	4246	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-28	4274	4281	1A,m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-29	7056	7062	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-3p	4320	4326	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	4320	4326	m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-30-5p	6249	6256	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
				hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	3327	3333	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	1325	1331	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-326	1967	1974	1A,m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-329	6993	6999	m8	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-34b	1649	1655	1A	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p	7093	7099	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-370	3588	3594	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-374	7093	7100	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	7126	7132	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-377	1553	1559	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-384	875	881	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-493-5p	4173	4179	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	5381	5387	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-542-3p	1719	1726	1A,m8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-543	4187	4193	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-7	6121	6128	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-9	5567	5573	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520	4146	4152	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	7206	7212	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
				hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
				hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.