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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MAP2K4

Summary

GeneID

6416

Symbol

MAP2K4

Synonyms

Description

mitogen-activated protein kinase kinase 4

Locus tag

Gene type

protein-coding

Map location

17p11.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 1.742

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0801

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

GMIP

0.92

0.75

C21orf30

0.92

0.81

ANKRD13B

0.92

0.76

TAS1R3

0.92

0.83

DCHS1

0.92

0.91

KDM6B

0.92

0.82

GTF2IRD1

0.91

0.77

PLEKHG2

0.91

0.92

PLXNA3

0.91

0.79

TRIOBP

0.91

0.93

Top 10 negatively co-expressed genes

C5orf53

-0.70

-0.76

OMG

-0.68

-0.79

ACOT13

-0.67

-0.75

PLA2G4A

-0.67

-0.79

FBXO2

-0.67

-0.66

ITM2B

-0.67

-0.71

ACYP2

-0.67

-0.73

CA4

-0.66

-0.74

CD9

-0.65

-0.74

ME1

-0.65

-0.68

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005515

protein binding

IPI

9808624 |15299019 |16533805

GO:0005524

ATP binding

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0004713

protein tyrosine kinase activity

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0007254

JNK cascade

TAS

7716521

GO:0007165

signal transduction

TAS

7716521

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	11707464
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	-	HPRD,BioGRID	11090355
DUSP22	JKAP \| JSP1 \| MKPX \| VHX	dual specificity phosphatase 22	-	HPRD	11346645
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	9006895
FLNC	ABP-280 \| ABP280A \| ABPA \| ABPL \| FLJ10186 \| FLN2	filamin C, gamma (actin binding protein 280)	-	HPRD,BioGRID	9006895
MAP2K7	Jnkk2 \| MAPKK7 \| MKK7 \| PRKMK7	mitogen-activated protein kinase kinase 7	Phenotypic Enhancement	BioGRID	11062067
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	MKK4 interacts with MEKK1. This interaction was modeled on a demonstrated interaction between human MKK4 and rat MEKK1.	BIND	15866172
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	MEKK1 phosphorylates MEK4.	BIND	10969079
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	-	HPRD,BioGRID	9182538
MAP3K11	MGC17114 \| MLK-3 \| MLK3 \| PTK1 \| SPRK	mitogen-activated protein kinase kinase kinase 11	Biochemical Activity	BioGRID	10187804
MAP3K12	DLK \| MUK \| ZPK \| ZPKP1	mitogen-activated protein kinase kinase kinase 12	-	HPRD	10187804
MAP3K2	MEKK2 \| MEKK2B	mitogen-activated protein kinase kinase kinase 2	-	HPRD	7997270
MAP3K4	FLJ42439 \| KIAA0213 \| MAPKKK4 \| MEKK4 \| MTK1 \| PRO0412	mitogen-activated protein kinase kinase kinase 4	-	HPRD,BioGRID	9841871
MAP3K4	FLJ42439 \| KIAA0213 \| MAPKKK4 \| MEKK4 \| MTK1 \| PRO0412	mitogen-activated protein kinase kinase kinase 4	MKK4 interacts with and is phosphorylated by MTK1.	BIND	15866172
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	12556533
MAP3K8	COT \| EST \| ESTF \| FLJ10486 \| TPL2 \| Tpl-2 \| c-COT	mitogen-activated protein kinase kinase kinase 8	-	HPRD,BioGRID	8631303
MAP4K2	BL44 \| GCK \| RAB8IP	mitogen-activated protein kinase kinase kinase kinase 2	Reconstituted Complex	BioGRID	9712898
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	-	HPRD,BioGRID	7716521
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	-	HPRD	9661668 \|11062067
			MKK4 phosphorylates JNK1. This interaction was modeled on a demonstrated interaction between MKK4 from an unspecified species and JNK1 from an unpsecified species.	BIND	12659851
			Biochemical Activity Phenotypic Enhancement Reconstituted Complex	BioGRID	9207092 \|11279118 \|11707464 \|12391307
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD,BioGRID	10523642 \|12189133
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD	12189133
SPAG9	FLJ13450 \| FLJ14006 \| FLJ26141 \| FLJ34602 \| HLC4 \| JLP \| KIAA0516 \| MGC117291 \| MGC14967 \| MGC74461 \| PHET \| PIG6	sperm associated antigen 9	-	HPRD,BioGRID	12391307
ZAK	AZK \| MLK7 \| MLT \| MLTK \| MRK \| mlklak	sterile alpha motif and leucine zipper containing kinase AZK	-	HPRD	11836244

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	2284	2290	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1001	1007	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
				hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	2178	2184	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
				hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-141/200a	75	81	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
				hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	5	11	1A	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-150	473	479	1A	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-188	2276	2282	1A	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-22	334	340	1A	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-25/32/92/363/367	508	515	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
				hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	282	288	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
				hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	871	877	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-339	976	982	1A	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-369-3p	2097	2103	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	2097	2104	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-431	44	50	m8	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-487b	265	271	m8	hsa-miR-487b	AAUCGUACAGGGUCAUCCACUU
miR-503	4	11	1A,m8	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.