Gene Page: NSD1

Summary
GeneID  64324
Symbol  NSD1
Synonyms  ARA267|DKFZp666C163|FLJ10684|FLJ22263|FLJ44628|KMT3B|SOTOS|STO
Description  nuclear receptor binding SET domain protein 1
See related  HGNC:14234|MIM:606681|Ensembl:ENSG00000165671|HPRD:09455|
Locus tag  -
Gene type  protein-coding
Map location  5q35.2-q35.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingISS-
GO:0003714transcription corepressor activityISS-
GO:0005515protein bindingIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008168methyltransferase activityIEA-
GO:0016922ligand-dependent nuclear receptor bindingISS-
GO:0042799histone lysine N-methyltransferase activity (H4-K20 specific)ISS-
GO:0030331estrogen receptor bindingISS-
GO:0046872metal ion bindingIEA-
GO:0050681androgen receptor bindingIDA11509567 
GO:0046965retinoid X receptor bindingISS-
GO:0046975histone lysine N-methyltransferase activity (H3-K36 specific)ISS-
GO:0046966thyroid hormone receptor bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS-
GO:0006350transcriptionIEA-
GO:0016568chromatin modificationIEA-
GO:0016571histone methylationISS-
GO:0045893positive regulation of transcription, DNA-dependentIDA11509567 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD11509567 
-HPRD,BioGRID11266437|11509567 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD9628876 
RARANR1B1 | RARretinoic acid receptor, alpha-HPRD9628876 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD9628876 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)-HPRD9628876 
ZNF496MGC15548 | NIZP1 | ZKSCAN17zinc finger protein 496-HPRD,BioGRID15169884 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LYSINE_DEGRADATION 4429All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREEN_DN 2512All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_27 158All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED 228119All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-378*285291m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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