Gene Page: ITSN1

Summary
GeneID  6453
Symbol  ITSN1
Synonyms  ITSN|MGC134948|MGC134949|SH3D1A|SH3P17
Description  intersectin 1 (SH3 domain protein)
See related  HGNC:6183|MIM:602442|Ensembl:ENSG00000205726|HPRD:03898|
Locus tag  -
Gene type  protein-coding
Map location  21q22.1-q22.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.0914 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SORD0.800.84
CASC30.800.74
NAB10.790.81
RPA10.790.81
BICD10.790.80
C14orf210.780.81
KPNB10.780.79
MYT10.780.65
ELAVL10.780.78
BRAP0.780.81
Top 10 negatively co-expressed genes
MT-CO2-0.54-0.65
AF347015.31-0.54-0.65
FXYD1-0.54-0.65
AF347015.8-0.53-0.64
AF347015.27-0.52-0.63
AF347015.33-0.52-0.61
AF347015.21-0.52-0.67
MT-CYB-0.52-0.62
IFI27-0.51-0.63
HIGD1B-0.50-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA-
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005085guanyl-nucleotide exchange factor activityNAS9799604 
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingNAS9799604 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12006984 |12812986 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048488synaptic vesicle endocytosisTASaxon, Synap, Neurotransmitter (GO term level: 7)9799604 
GO:0007242intracellular signaling cascadeIEA-
GO:0007264small GTPase mediated signal transductionIEA-
GO:0035023regulation of Rho protein signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0012505endomembrane systemIEA-
GO:0005622intracellularIEA-
GO:0016020membraneIEA-
GO:0030027lamellipodiumIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASAP1AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14PArfGAP with SH3 domain, ankyrin repeat and PH domain 1DDEF1 (AMAP1) interacts with an unspecified isoform of ITSN1 (Intersectin1).BIND15719014 
ASAP2AMAP2 | CENTB3 | DDEF2 | FLJ42910 | KIAA0400 | PAG3 | PAP | Pap-alpha | SHAG1ArfGAP with SH3 domain, ankyrin repeat and PH domain 2DDEF2 (AMAP2) interacts with an unspecified isoform of ITSN1 (Intersectin1).BIND15719014 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Cdc42 specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor ITSN1.BIND12006984 
-HPRD,BioGRID11584276 
CDGAPKIAA1204 | MGC138368 | MGC138370Cdc42 GTPase-activating protein-HPRD11744688 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1DISC-1 interacts with ITSN.BIND12812986 
Two-hybridBioGRID12812986 
DNM1DNMdynamin 1-HPRD10373452 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1Two-hybridBioGRID16169070 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2-HPRD,BioGRID12389031 
KIF5AD12S1889 | MY050 | NKHC | SPG10kinesin family member 5ATwo-hybridBioGRID16169070 
MRPL20L20mt | MGC4779 | MGC74465 | MRP-L20mitochondrial ribosomal protein L20Two-hybridBioGRID16169070 
SCAMP1SCAMP | SCAMP37secretory carrier membrane protein 1-HPRD,BioGRID10777571 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Two-hybridBioGRID16169070 
SNAP23HsT17016 | SNAP23A | SNAP23Bsynaptosomal-associated protein, 23kDa-HPRD,BioGRID10373452 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDa-HPRD,BioGRID10373452 
SNX5FLJ10931sorting nexin 5Two-hybridBioGRID16169070 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID10716926 
STON2STN2 | STNB | STNB2stonin 2-HPRD,BioGRID11381094 
TSG101TSG10 | VPS23tumor susceptibility gene 101Two-hybridBioGRID15256501 
UNC119HRG4unc-119 homolog (C. elegans)Two-hybridBioGRID16169070 
WASLDKFZp779G0847 | MGC48327 | N-WASP | NWASPWiskott-Aldrich syndrome-like-HPRD,BioGRID11584276 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_CDC42_REG_PATHWAY 3022All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY 4135All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES 11381All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 4333All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
PIEPOLI_LGI1_TARGETS_DN 146All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5 9459All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_MCF10A 2013All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_60_MCF10A 5742All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP 13995All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
RUIZ_TNC_TARGETS_UP 153107All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MF_DN 4128All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR 15288All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/981641701Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-102462531A,m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-141/200a5025091A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-15082881Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-181101310191Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-197527591A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-19059651Ahsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-1949379441A,m8hsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-224104110m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p104810551A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3266975m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-34/4496470m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-34b126132m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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