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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SIAH1

Summary

GeneID

6477

Symbol

SIAH1

Synonyms

FLJ08065|HUMSIAH|Siah-1|Siah-1a|hSIAH1

Description

seven in absentia homolog 1 (Drosophila)

Locus tag

Gene type

protein-coding

Map location

16q12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.01775

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

MMRN2

0.80

0.81

LRRC32

0.79

0.80

CXorf36

0.75

0.77

SLCO2B1

0.75

0.77

TGM2

0.74

0.75

VWF

0.72

0.76

TLN1

0.72

0.68

CSPG4

0.70

0.76

CD34

0.70

0.73

ENG

0.70

0.74

Top 10 negatively co-expressed genes

MTERFD3

-0.51

-0.56

SNHG12

-0.51

-0.55

ANAPC4

-0.51

-0.53

C6orf203

-0.50

-0.51

NDUFAF2

-0.50

-0.54

ST20

-0.50

-0.57

C8orf59

-0.50

-0.60

MTIF3

-0.50

-0.54

FRG1

-0.49

-0.52

PDCD5

-0.48

-0.49

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016874

ligase activity

IEA

GO:0016881

acid-amino acid ligase activity

IEA

GO:0008270

zinc ion binding

IDA

11863358

GO:0008022

protein C-terminus binding

IPI

11389840

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007411

axon guidance

TAS

axon (GO term level: 13)

9334332

GO:0007399

nervous system development

TAS

neurite (GO term level: 5)

9334332

GO:0006508

proteolysis

TAS

9334332

GO:0006511

ubiquitin-dependent protein catabolic process

IEA

GO:0007283

spermatogenesis

IEA

GO:0007049

cell cycle

IEA

GO:0009653

anatomical structure morphogenesis

TAS

9403064

GO:0006915

apoptosis

TAS

9403064

GO:0007275

multicellular organismal development

IEA

GO:0030154

cell differentiation

IEA

GO:0030163

protein catabolic process

IDA

11389840

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

GO:0005737

cytoplasm

TAS

9334332

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AFF4	AF5Q31 \| MCEF \| MGC75036	AF4/FMR2 family, member 4	Two-hybrid	BioGRID	16189514
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	-	HPRD,BioGRID	11389840
BAG1	RAP46	BCL2-associated athanogene	-	HPRD,BioGRID	9582267
CACYBP	GIG5 \| MGC87971 \| PNAS-107 \| RP1-102G20.6 \| S100A6BP \| SIP	calcyclin binding protein	-	HPRD,BioGRID	11389839
DAB1	-	disabled homolog 1 (Drosophila)	-	HPRD,BioGRID	12646221
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	-	HPRD,BioGRID	9858595
			DCC interacts with Siah-1.	BIND	9334332
			hSiah1 interacts with DCC cytoplasmic domain.	BIND	9334332
EIF3J	EIF3S1 \| eIF3-alpha \| eIF3-p35	eukaryotic translation initiation factor 3, subunit J	-	HPRD,BioGRID	9822659
KHDRBS3	Etle \| SALP \| SLM-2 \| SLM2 \| T-STAR \| TSTAR \| etoile	KH domain containing, RNA binding, signal transduction associated 3	-	HPRD,BioGRID	15163637
KIF22	KID \| KNSL4 \| OBP \| OBP-1 \| OBP-2	kinesin family member 22	-	HPRD,BioGRID	11146551
NUMB	S171	numb homolog (Drosophila)	-	HPRD,BioGRID	11752454
PEG10	Edr \| HB-1 \| KIAA1051 \| MEF3L \| Mar2 \| Mart2 \| RGAG3	paternally expressed 10	-	HPRD,BioGRID	12810624
PEG3	DKFZp781A095 \| KIAA0287 \| PW1 \| ZSCAN24	paternally expressed 3	-	HPRD,BioGRID	10681424
POU2AF1	BOB1 \| OBF-1 \| OBF1 \| OCAB	POU class 2 associating factor 1	-	HPRD,BioGRID	11483517 \|11483518
RBBP8	CTIP \| RIM	retinoblastoma binding protein 8	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14654780
SIAH1	FLJ08065 \| HUMSIAH \| Siah-1 \| Siah-1a \| hSIAH1	seven in absentia homolog 1 (Drosophila)	-	HPRD,BioGRID	9582267
SKP1	EMC19 \| MGC34403 \| OCP-II \| OCP2 \| SKP1A \| TCEB1L \| p19A	S-phase kinase-associated protein 1	-	HPRD	11389839
SYP	-	synaptophysin	-	HPRD,BioGRID	11786535
TBL1X	EBI \| SMAP55 \| TBL1	transducin (beta)-like 1X-linked	-	HPRD,BioGRID	11389839
TUBA1A	B-ALPHA-1 \| FLJ25113 \| LIS3 \| TUBA3	tubulin, alpha 1a	-	HPRD	11146551
TUBA1B	K-ALPHA-1	tubulin, alpha 1b	-	HPRD	11146551
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	11146551
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	tubulin, alpha 4a	-	HPRD	11146551
TUBA8	TUBAL2	tubulin, alpha 8	-	HPRD	11146551
UBE2D1	E2(17)KB1 \| SFT \| UBC4/5 \| UBCH5 \| UBCH5A	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	-	HPRD,BioGRID	11389839
UBE2E3	UBCH9 \| UbcM2	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	Two-hybrid	BioGRID	11389839
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Ubc9 interacts with Siah-1.	BIND	9334332
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	hSiah1 interacts with Ubc9.	BIND	9334332
VAV1	VAV	vav 1 guanine nucleotide exchange factor	Two-hybrid	BioGRID	10207103

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_P53_SIGNALING_PATHWAY	69	45	All SZGR genes in this pathway
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	138	98	All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY	151	112	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING	41	30	All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN	406	230	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_UP	78	48	All SZGR genes in this pathway
BILBAN_B_CLL_LPL_UP	63	39	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN	485	334	All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP	55	40	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	1142	669	All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_G1_G2_DN	25	18	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_UP	44	26	All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D4	55	37	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_DN	123	86	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN	312	203	All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION	88	65	All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP	226	164	All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE	49	35	All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP	673	430	All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN	593	372	All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN	591	366	All SZGR genes in this pathway
MATZUK_SPERMATOCYTE	72	55	All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP	245	159	All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN	435	289	All SZGR genes in this pathway
MONTERO_THYROID_CANCER_POOR_SURVIVAL_DN	11	6	All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1	467	251	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-129-5p	988	995	1A,m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	988	995	1A,m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-135	390	396	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	390	396	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-140	198	204	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-141/200a	25	31	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	25	31	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	446	452	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-193	22	28	m8	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	22	28	m8	hsa-miR-193b	AACUGGCCCUCAAAGUCCCGCUUU
miR-200bc/429	942	948	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-205	112	118	m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-299-5p	196	203	1A,m8	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-3p	203	210	1A,m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	203	210	1A,m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-329	466	472	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-381	901	907	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-450	988	994	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-486	143	149	1A	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG
miR-488	1030	1036	m8	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.