Gene Page: SKIL

Summary
GeneID  6498
Symbol  SKIL
Synonyms  SNO|SnoA|SnoN
Description  SKI-like oncogene
See related  HGNC:10897|MIM:165340|Ensembl:ENSG00000136603|HPRD:01319|
Locus tag  -
Gene type  protein-coding
Map location  3q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0108 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GALNT90.860.89
FSTL40.860.79
SYT70.860.84
SYNGR10.850.84
ABCG40.840.88
KNDC10.840.82
AC013418.10.840.80
AC135048.10.840.79
DNM10.830.88
MCHR10.830.84
Top 10 negatively co-expressed genes
FAM36A-0.43-0.35
GTF3C6-0.43-0.38
C9orf46-0.43-0.43
RPS20-0.40-0.49
RBMX2-0.40-0.40
RPL27A-0.39-0.49
RPS6-0.39-0.42
EXOSC8-0.39-0.32
RPL35-0.39-0.44
RPL31-0.39-0.40
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003714transcription corepressor activityTAS10531062 
GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activityTAS10531062 
GO:0005515protein bindingTAS10531062 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006366transcription from RNA polymerase II promoterTAS10531062 
GO:0007165signal transductionTAS10531062 
GO:0007275multicellular organismal developmentNAS9207045 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC16APC6cell division cycle 16 homolog (S. cerevisiae)-HPRD11691834 
CDC27APC3 | CDC27Hs | D0S1430E | D17S978E | HNUCcell division cycle 27 homolog (S. cerevisiae)-HPRD11691834 
CPNE1COPN1 | CPN1 | MGC1142copine I-HPRD12522145 
CPNE2COPN2 | CPN2 | DKFZp686E06199 | MGC16924copine II-HPRD12522145 
CPNE4COPN4 | CPN4 | MGC15604copine IV-HPRD12522145 
FZR1CDC20C | CDH1 | FZR | FZR2 | HCDH | HCDH1 | KIAA1242fizzy/cell division cycle 20 related 1 (Drosophila)-HPRD,BioGRID11691834 
SKISKVv-ski sarcoma viral oncogene homolog (avian)-HPRD,BioGRID9927733 
SKILSNO | SnoA | SnoNSKI-like oncogeneReconstituted ComplexBioGRID9927733 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1Smad1 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad1.BIND12426322 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2Smad2 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad2.BIND12426322 
-HPRD,BioGRID10531062 |11691834 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3Smad3 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad3.BIND12426322 
-HPRD,BioGRID10531062 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Smad4 interacts with SnoN. This interaction was modeled on a demonstrated interaction between human Smad4 and SnoN from an unspecified species.BIND15761153 
-HPRD,BioGRID10531062 
SMURF2DKFZp686F0270 | MGC138150SMAD specific E3 ubiquitin protein ligase 2-HPRD,BioGRID11389444 
SNW1Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIPSNW domain containing 1Phenotypic SuppressionBioGRID11278756 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_TGFB_PATHWAY 1914All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 3826All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 2014All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN 10371All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
STOSSI_RESPONSE_TO_ESTRADIOL 5035All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_DN 116All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_UP 1917All SZGR genes in this pathway
VISALA_RESPONSE_TO_HEAT_SHOCK_AND_AGING_DN 1412All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
QI_PLASMACYTOMA_DN 10063All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP 10968All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_DN 187109All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_TARGETS_UP 4833All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-3305864m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-4101451511Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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