Gene Page: SLC4A1

Summary
GeneID  6521
Symbol  SLC4A1
Synonyms  AE1|BND3|CD233|DI|EMPB3|EPB3|FR|MGC116750|MGC116753|MGC126619|MGC126623|RTA1A|SW|WD|WD1|WR
Description  solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
See related  HGNC:11027|MIM:109270|Ensembl:ENSG00000004939|HPRD:00175|
Locus tag  -
Gene type  protein-coding
Map location  17q21-q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.061 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TYW30.780.54
NECAB10.780.66
SLC3A10.750.72
GLIPR10.740.67
EIF5A20.730.67
NAPEPLD0.720.63
FGFR1OP20.720.68
ENPP40.720.67
KRT222P0.720.73
NCOA70.720.70
Top 10 negatively co-expressed genes
TBC1D10A-0.39-0.35
OLFM2-0.39-0.34
BCL7C-0.34-0.43
WDR86-0.34-0.40
NME4-0.34-0.48
SIGIRR-0.34-0.45
EMID1-0.34-0.38
FADS2-0.34-0.31
SEMA4B-0.33-0.33
EFEMP2-0.33-0.40
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI16669616 
GO:0005452inorganic anion exchanger activityIEA-
GO:0005215transporter activityIEA-
GO:0008509anion transmembrane transporter activityIEA-
GO:0008509anion transmembrane transporter activityTAS4027230 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
GO:0006820anion transportIEA-
GO:0006820anion transportTAS4027230 
GO:0006810transportIEA-
GO:0006873cellular ion homeostasisTAS8841202 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS1527044 
GO:0005887integral to plasma membraneTAS4027230 
GO:0030863cortical cytoskeletonIDA16669616 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANK1ANK | SPH1 | SPH2ankyrin 1, erythrocytic-HPRD6449514 
Affinity Capture-WesternBioGRID8227202 
CA2CA-II | CAII | Car2carbonic anhydrase II-HPRD,BioGRID9774471 |10820026 
|11063570 
CA4CAIV | Car4 | RP17carbonic anhydrase IV-HPRD,BioGRID11994299 
CANXCNX | FLJ26570 | IP90 | P90calnexin-HPRD,BioGRID10364201 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD1639060 
EPB42MGC116735 | MGC116737 | PAerythrocyte membrane protein band 4.2Protein-peptideBioGRID7626035 
PLDNPA | PALLIDpallidin homolog (mouse)-HPRD2968981 
RHAGCD241 | RH2 | RH50A | Rh50 | Rh50GP | SLC42A1Rh-associated glycoprotein-HPRD12531814 
SLC4A1AE1 | BND3 | CD233 | DI | EMPB3 | EPB3 | FR | MGC116750 | MGC116753 | MGC126619 | MGC126623 | RTA1A | SW | WD | WD1 | WRsolute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)-HPRD,BioGRID7479704 |11049968 
SLC4A1APFLJ10624 | FLJ41004 | HLC3 | MGC120646 | MGC120648solute carrier family 4 (anion exchanger), member 1, adaptor proteinReconstituted Complex
Two-hybrid		BioGRID9422766 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES 9465All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
CEBALLOS_TARGETS_OF_TP53_AND_MYC_DN 3831All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_DN 4524All SZGR genes in this pathway
WELCH_GATA1_TARGETS 2212All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K27ME3 7035All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
STEINER_ERYTHROCYTE_MEMBRANE_GENES 1510All SZGR genes in this pathway


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