Gene Page: SLC7A2

Summary
GeneID  6542
Symbol  SLC7A2
Synonyms  ATRC2|CAT-2|HCAT2
Description  solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
See related  HGNC:11060|MIM:601872|Ensembl:ENSG00000003989|HPRD:03524|
Locus tag  -
Gene type  protein-coding
Map location  8p22-p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ERMN0.900.90
TMEM1440.900.89
ASPA0.880.90
UGT80.880.86
FOLH10.880.80
ABCA80.870.77
PLP10.870.89
CTNNA30.860.75
CDH190.860.85
ENPP20.860.90
Top 10 negatively co-expressed genes
NKIRAS2-0.65-0.73
KIAA1949-0.64-0.78
ZNF821-0.64-0.74
TUBB2B-0.63-0.80
C17orf70-0.63-0.74
GMIP-0.63-0.75
PODXL2-0.63-0.72
CRMP1-0.62-0.72
DBN1-0.62-0.74
HN1-0.62-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0015174basic amino acid transmembrane transporter activityTAS8954799 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006520amino acid metabolic processTAS8954799 
GO:0006810transportTAS8954799 
GO:0006865amino acid transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS8954799 
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS8954799 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE 3121All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES 9465All SZGR genes in this pathway
REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS 4936All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
WEI_MIR34A_TARGETS 14897All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
SANA_TNF_SIGNALING_UP 8356All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
NIELSEN_SCHWANNOMA_DN 189All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_UP 11665All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206192619331A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-15/16/195/424/49753515357m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-27235323591Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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