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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SLC9A2

Summary

GeneID

6549

Symbol

SLC9A2

Synonyms

NHE2

Description

solute carrier family 9 (sodium/hydrogen exchanger), member 2

Locus tag

Gene type

protein-coding

Map location

2q11.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0004

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

NPTXR

0.79

0.65

FAM120A

0.75

TRIM9

0.75

0.77

STIM1

0.75

0.78

C2CD2L

0.75

0.76

SLC8A2

0.75

0.65

SLC25A22

0.75

0.71

OTUD7A

0.74

0.77

IQSEC2

0.74

0.69

WSCD2

0.74

0.73

Top 10 negatively co-expressed genes

FAM36A

-0.40

-0.42

C8orf59

-0.39

-0.46

RP9P

-0.38

-0.50

C21orf57

-0.38

-0.43

RPL31

-0.37

-0.48

NDUFAF2

-0.37

-0.40

FABP7

-0.36

-0.42

PFDN5

-0.35

-0.42

RPL24

-0.35

-0.46

RPL35

-0.35

-0.46

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0015385

sodium:hydrogen antiporter activity

TAS

7683411

GO:0015299

solute:hydrogen antiporter activity

IEA

GO:0015297

antiporter activity

IEA

GO:0031402

sodium ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008104

protein localization

IEA

GO:0006814

sodium ion transport

IEA

GO:0006811

ion transport

IEA

GO:0006885

regulation of pH

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

TAS

7683411

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD,BioGRID	10187839
CHP	SLC9A1BP	calcium binding protein P22	Reconstituted Complex	BioGRID	12576672
CHP	SLC9A1BP	calcium binding protein P22	-	HPRD	8901634\|11350981
CHP2	-	calcineurin B homologous protein 2	Reconstituted Complex	BioGRID	12576672
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	10187839
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	10187839
SPTA1	EL2 \| SPTA	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	-	HPRD,BioGRID	10187839
SPTAN1	(ALPHA)II-SPECTRIN \| FLJ44613 \| NEAS	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	-	HPRD	10579058
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	10187839

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES	413	270	All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	241	157	All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	94	65	All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN	162	116	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP	487	286	All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS	1038	678	All SZGR genes in this pathway
BENPORATH_EED_TARGETS	1062	725	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS	652	441	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
WONG_MITOCHONDRIA_GENE_MODULE	217	122	All SZGR genes in this pathway
ZHENG_IL22_SIGNALING_DN	42	26	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_BRCA1_DN	44	28	All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6	456	285	All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	1069	729	All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	349	234	All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3	341	243	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D	280	158	All SZGR genes in this pathway
KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES	275	155	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	264	270	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	264	270	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-130/301	1123	1130	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-182	1708	1714	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-19	1122	1128	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1122	1128	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-26	277	283	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
				hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-495	1139	1145	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-96	1707	1714	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.