Gene Page: SLC11A1

Summary
GeneID  6556
Symbol  SLC11A1
Synonyms  LSH|NRAMP|NRAMP1
Description  solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
See related  HGNC:10907|MIM:600266|Ensembl:ENSG00000018280|HPRD:02601|
Locus tag  -
Gene type  protein-coding
Map location  2q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
USP70.860.89
EHBP10.840.86
CLIP10.840.87
MYT1L0.840.89
ZMYND110.840.86
SPTAN10.830.86
PRDM20.830.88
AC020663.10.830.84
NOL40.830.87
MIA30.820.86
Top 10 negatively co-expressed genes
FXYD1-0.70-0.72
ENHO-0.70-0.80
HIGD1B-0.70-0.76
AF347015.31-0.69-0.72
MT-CO2-0.69-0.72
METRN-0.68-0.77
C1orf54-0.67-0.79
IFI27-0.67-0.70
AC021016.1-0.67-0.72
AF347015.21-0.67-0.71
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0005215transporter activityIEA-
GO:0005215transporter activityTAS8537108 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009617response to bacteriumTAS7717395 
GO:0006826iron ion transportIEA-
GO:0006811ion transportIEA-
GO:0006810transportIEA-
GO:0006955immune responseNAS10967134 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005624membrane fractionTAS8537108 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS8537108 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LYSOSOME 12183All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS 3315All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS 8954All SZGR genes in this pathway
REACTOME_METAL_ION_SLC_TRANSPORTERS 2213All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
SHIPP_DLBCL_CURED_VS_FATAL_UP 3922All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
LIAN_LIPA_TARGETS_6M 7447All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LIAN_LIPA_TARGETS_3M 5936All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
HOLLEMAN_PREDNISOLONE_RESISTANCE_ALL_DN 118All SZGR genes in this pathway
HOLLEMAN_DAUNORUBICIN_ALL_UP 75All SZGR genes in this pathway


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