Gene Page: SLC18A2

Summary
GeneID  6571
Symbol  SLC18A2
Synonyms  MGC120477|MGC120478|MGC26538|SVAT|SVMT|VAT2|VMAT2
Description  solute carrier family 18 (vesicular monoamine), member 2
See related  HGNC:10935|MIM:193001|Ensembl:ENSG00000165646|HPRD:01896|
Locus tag  -
Gene type  protein-coding
Map location  10q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ARMCX10.950.95
CCT6A0.950.96
KLHL70.940.95
CCT20.930.96
TCP10.930.95
POLR2B0.930.94
ZUFSP0.930.92
GDI20.930.94
MATR30.930.92
ACTR30.930.94
Top 10 negatively co-expressed genes
HLA-F-0.73-0.84
MT-CO2-0.70-0.85
AF347015.33-0.70-0.85
FXYD1-0.70-0.87
TSC22D4-0.69-0.82
AF347015.31-0.69-0.83
AF347015.27-0.69-0.83
HEPN1-0.69-0.78
AIFM3-0.69-0.79
IFI27-0.69-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005215transporter activityIEA-
GO:0008504monoamine transmembrane transporter activityTAS8095030 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0015844monoamine transportTAS8095030 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS8095030 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS8095030 
GO:0031410cytoplasmic vesicleIEA-
GO:0030659cytoplasmic vesicle membraneIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PARKINSONS_DISEASE 13378All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 1111All SZGR genes in this pathway
REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 1010All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS 8954All SZGR genes in this pathway
REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS 1712All SZGR genes in this pathway
REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS 2716All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_DN 8253All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
LEIN_PONS_MARKERS 8959All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_OLD 1310All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_OLD 2518All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_DN 2112All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p214220m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-3811952011Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-5052062131A,m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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