Gene Page: SLC22A5

Summary
GeneID  6584
Symbol  SLC22A5
Synonyms  CDSP|FLJ46769|OCTN2|OCTN2VT
Description  solute carrier family 22 (organic cation/carnitine transporter), member 5
See related  HGNC:10969|MIM:603377|Ensembl:ENSG00000197375|HPRD:04539|
Locus tag  -
Gene type  protein-coding
Map location  5q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
ExpressionExpressionP value: 1.629 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF6890.930.95
ZNF5740.930.94
SMCR70.930.92
C17orf1000.930.93
C7orf130.930.94
ZNF8350.930.95
CHMP70.930.94
C14orf40.930.95
ZNRF10.930.94
ZNF7460.920.94
Top 10 negatively co-expressed genes
AF347015.31-0.73-0.87
MT-CO2-0.72-0.88
AF347015.33-0.72-0.87
AF347015.27-0.72-0.87
MT-CYB-0.70-0.86
AF347015.8-0.70-0.88
FXYD1-0.69-0.84
S100B-0.69-0.82
C5orf53-0.69-0.76
COPZ2-0.68-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005215transporter activityIEA-
GO:0015293symporter activityIEA-
GO:0015226carnitine transporter activityTAS9685390 
GO:0015075ion transmembrane transporter activityIEA-
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006814sodium ion transportIEA-
GO:0006811ion transportIEA-
GO:0006810transportIEA-
GO:0015879carnitine transportTAS9685390 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS9685390 |9916797 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS 8954All SZGR genes in this pathway
REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT 139All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_UP 3728All SZGR genes in this pathway
SWEET_KRAS_TARGETS_UP 8451All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
WENG_POR_TARGETS_GLOBAL_DN 2314All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50612901296m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-182103910451Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-96103810451A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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