Gene Page: SMO

Summary
GeneID  6608
Symbol  SMO
Synonyms  Gx|SMOH
Description  smoothened homolog (Drosophila)
See related  HGNC:11119|MIM:601500|Ensembl:ENSG00000128602|HPRD:03294|
Locus tag  -
Gene type  protein-coding
Map location  7q32.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CD99L20.880.86
MAP7D20.870.87
PLEKHB20.870.86
AARS0.860.85
DDHD20.860.85
MAP1A0.860.84
RNF1570.860.84
NSF0.860.86
EHD30.860.85
ATP6V0A10.860.85
Top 10 negatively co-expressed genes
C1orf61-0.42-0.43
RPL35-0.41-0.47
IL32-0.41-0.38
SIGIRR-0.41-0.48
CLEC3B-0.41-0.47
BCL7C-0.41-0.51
FAM159B-0.40-0.60
AC006276.2-0.40-0.41
GNG11-0.40-0.33
RAMP2-0.40-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS9422511 
GO:0004930G-protein coupled receptor activityIEA-
GO:0005515protein bindingTAS8906787 
GO:0004926non-G-protein coupled 7TM receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0021953central nervous system neuron differentiationIEAneuron (GO term level: 9)-
GO:0001755neural crest cell migrationIEA-
GO:0001570vasculogenesisIEA-
GO:0001649osteoblast differentiationIEA-
GO:0002052positive regulation of neuroblast proliferationIEA-
GO:0003007heart morphogenesisIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007368determination of left/right symmetryIEA-
GO:0009953dorsal/ventral pattern formationIEA-
GO:0048468cell developmentIEA-
GO:0007389pattern specification processIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0021938smoothened signaling pathway involved in regulation of granule cell precursor cell proliferationIEA-
GO:0043392negative regulation of DNA bindingIEA-
GO:0021696cerebellar cortex morphogenesisIEA-
GO:0048589developmental growthIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneTAS9422511 
GO:0005929ciliumIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2Beta-arr2 interacts with Smo. This interaction was modeled on a demonstrated interaction between Beta-arr2 and Smo both from an unspecified species.BIND15618519 
PTCH1BCNS | FLJ26746 | FLJ42602 | HPE7 | NBCCS | PTC | PTC1 | PTCH | PTCH11patched homolog 1 (Drosophila)-HPRD,BioGRID9811851 
PTCH2-patched homolog 2 (Drosophila)-HPRD,BioGRID9811851 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_SHH_PATHWAY 1615All SZGR genes in this pathway
PID_HEDGEHOG_2PATHWAY 2217All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
DOANE_BREAST_CANCER_CLASSES_DN 3426All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_DN 2113All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C5 2111All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_24HR 2013All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7 9863All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_VIA_ATM_NOT_VIA_NFKB_UP 4932All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_1HR_DN 108All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_TOP20_DN 1812All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-381108610921Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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