Gene Page: SRPK1

Summary
GeneID  6732
Symbol  SRPK1
Synonyms  SFRSK1
Description  SFRS protein kinase 1
See related  HGNC:11305|MIM:601939|Ensembl:ENSG00000096063|HPRD:15992|
Locus tag  -
Gene type  protein-coding
Map location  6p21.3-p21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HERC60.880.72
MX10.800.55
IFIT30.780.44
IFIT10.770.51
ATPAF10.750.73
C1QB0.750.58
CD590.750.65
PPT10.750.81
AC068989.20.750.61
HSD17B120.740.78
Top 10 negatively co-expressed genes
TMEM88-0.41-0.47
EGFL8-0.40-0.39
RP9P-0.38-0.53
MYLK2-0.36-0.40
AC005921.3-0.36-0.47
AC011475.1-0.36-0.39
SLC38A5-0.35-0.40
AL022328.1-0.34-0.46
RAMP2-0.34-0.44
C1orf86-0.34-0.30
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA11509566 
GO:0005515protein bindingIPI10196197 |11509566 |17353931 
GO:0005524ATP bindingIDA11509566 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIDA11509566 
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008380RNA splicingTAS8208298 
GO:0006468protein amino acid phosphorylationIDA11509566 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007243protein kinase cascadeIDA11509566 
GO:0007059chromosome segregationIDA15034300 
GO:0030154cell differentiationIEA-
GO:0050684regulation of mRNA processingIDA8208298 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA11509566 
GO:0005737cytoplasmIDA11509566 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CROPLUC7A | OA48-18cisplatin resistance-associated overexpressed proteinBiochemical ActivityBioGRID12565863 
FERMT1C20orf42 | DTGCU2 | FLJ20116 | FLJ23423 | KIND1 | UNC112A | URP1fermitin family homolog 1 (Drosophila)-HPRD9472028 
LBRDHCR14B | FLJ43126 | LMN2R | MGC9041 | PHAlamin B receptor-HPRD10049757 |10390541 
MBPMGC99675myelin basic protein-HPRD10390541 
PRM1P1protamine 1-HPRD,BioGRID10390541 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
SAFBDKFZp779C1727 | HAP | HET | SAFB1scaffold attachment factor B-HPRD11509566 
SFRS1ASF | MGC5228 | SF2 | SF2p33 | SRp30asplicing factor, arginine/serine-rich 1-HPRD8208298 |8798720 
|9472028 |10390541 
Affinity Capture-Western
Biochemical Activity
Far Western
Reconstituted Complex		BioGRID9472028 |10196197 
|12565863 |17517895 
SFRS12DKFZp564B176 | MGC133045 | SRrp508 | SRrp86splicing factor, arginine/serine-rich 12-HPRD14559993 
SFRS2IPCASP11 | SIP1 | SRRP129splicing factor, arginine/serine-rich 2, interacting protein-HPRD8208298 
SFRS3SRp20splicing factor, arginine/serine-rich 3-HPRD8208298 |10390541 
SFRS4SRP75splicing factor, arginine/serine-rich 4-HPRD8208298 |10390541 
SFRS5HRS | SRP40splicing factor, arginine/serine-rich 5-HPRD8208298 |10390541 
SFRS6B52 | FLJ08061 | MGC5045 | SRP55splicing factor, arginine/serine-rich 6-HPRD8208298 |10340541 
SNRNP70RNPU1Z | RPU1 | SNRP70 | U170K | U1AP | U1RNPsmall nuclear ribonucleoprotein 70kDa (U1)Affinity Capture-Western
Biochemical Activity		BioGRID9472028 |12417631 
U2AF1DKFZp313J1712 | FP793 | RN | RNU2AF1 | U2AF35 | U2AFBPU2 small nuclear RNA auxiliary factor 1-HPRD9472028 
U2AF2U2AF65U2 small nuclear RNA auxiliary factor 2-HPRD9472028 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN 4734All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
SCHUHMACHER_MYC_TARGETS_UP 8057All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
NUMATA_CSF3_SIGNALING_VIA_STAT3 2217All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
FINETTI_BREAST_CANCER_KINOME_RED 1611All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE 8166All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_WITH_EPCAM_UP 5325All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_UP 7253All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137182818351A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-139169517011Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-15/16/195/424/497118111881A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d11041110m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1822212271Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-18621992205m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-2612401246m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-485-5p251257m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-503118211881Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-92232291Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-962212271Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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