Gene Page: STX4

Summary
GeneID  6810
Symbol  STX4
Synonyms  STX4A|p35-2
Description  syntaxin 4
See related  HGNC:11439|MIM:186591|Ensembl:ENSG00000103496|HPRD:01722|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.015 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DOCK20.840.76
CD680.840.73
ITGB20.830.77
NCKAP1L0.830.75
HCK0.820.69
SIGLEC100.790.71
LCP10.790.71
CX3CR10.780.78
CSF1R0.770.79
SASH30.770.61
Top 10 negatively co-expressed genes
MT-CO2-0.27-0.33
FXYD1-0.27-0.30
CXCL14-0.27-0.26
MT1G-0.26-0.30
S100A13-0.26-0.26
MYL3-0.25-0.27
AC098691.2-0.25-0.31
AF347015.18-0.25-0.30
CSAG1-0.25-0.29
AF347015.21-0.25-0.29
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005484SNAP receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006836neurotransmitter transportIEAneuron, Neurotransmitter (GO term level: 5)-
GO:0006886intracellular protein transportIEA-
GO:0016192vesicle-mediated transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10856305 
GO:0005773vacuoleTAS16339081 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIDA18029348 
GO:0016323basolateral plasma membraneIDA16339081 
GO:0031012extracellular matrixIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NAPASNAPAN-ethylmaleimide-sensitive factor attachment protein, alphaAffinity Capture-Western
Two-hybrid		BioGRID16189514 
NSFSKD2N-ethylmaleimide-sensitive factor-HPRD8973549 
RAB11AMGC1490 | YL8RAB11A, member RAS oncogene family-HPRD12435603 
RAB4AHRES-1/RAB4 | RAB4RAB4A, member RAS oncogene family-HPRD,BioGRID11063739 
RAB5ARAB5RAB5A, member RAS oncogene family-HPRD,BioGRID11884531 
SEPT5CDCREL | CDCREL-1 | CDCREL1 | H5 | PNUTL1septin 5-HPRD,BioGRID11880646 
SNAP23HsT17016 | SNAP23A | SNAP23Bsynaptosomal-associated protein, 23kDa-HPRD,BioGRID9168999 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDa-HPRD8760387 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID7768895 |8663154 
|9852078 |10194441 
SNAP29CEDNIK | FLJ21051 | SNAP-29synaptosomal-associated protein, 29kDaReconstituted ComplexBioGRID9852078 
STXBP1EIEE4 | MUNC18-1 | UNC18 | hUNC18 | rbSec1syntaxin binding protein 1Affinity Capture-Western
Reconstituted Complex		BioGRID7768895 |12773094 
STXBP2Hunc18b | MUNC18-2 | UNC18-2 | UNC18B | pp10122syntaxin binding protein 2Reconstituted ComplexBioGRID7768895 
STXBP3MUNC18-3 | MUNC18C | PSP | UNC-18Csyntaxin binding protein 3-HPRD10194441 
Affinity Capture-Western
Two-hybrid		BioGRID12773094 |12832401 
STXBP4FLJ16496 | MGC149829 | MGC50337 | Synipsyntaxin binding protein 4-HPRD10394363 |12855681 
STXBP5FLJ30922 | LGL3 | LLGL3 | MGC141942 | MGC141968 | Nbla04300syntaxin binding protein 5 (tomosyn)Reconstituted Complex
Two-hybrid		BioGRID12832401 
STXBP6FLJ39638 | HSPC156 | amisynsyntaxin binding protein 6 (amisyn)-HPRD12145319 
SYT1DKFZp781D2042 | P65 | SVP65 | SYTsynaptotagmin IReconstituted ComplexBioGRID10397765 
SYT4HsT1192 | KIAA1342synaptotagmin IV-HPRD10397765 
SYT7IPCA-7 | MGC150517 | PCANAP7 | SYT-VIIsynaptotagmin VII-HPRD7791877 
TXLNADKFZp451J0118 | IL14 | MGC118870 | MGC118871 | RP4-622L5.4 | TXLNtaxilin alphaReconstituted ComplexBioGRID12558796 
TXLNBC6orf198 | DKFZp451A175 | LST001 | MDP77 | dJ522B19.2taxilin beta-HPRD,BioGRID15184072 
VAMP1DKFZp686H12131 | SYB1 | VAMP-1vesicle-associated membrane protein 1 (synaptobrevin 1)Two-hybridBioGRID8760387 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)Affinity Capture-Western
Two-hybrid		BioGRID8760387 |10194441 
|10820264 |12517971 
-HPRD8760387 |12417022 
|12517971|8770861 
VAMP3CEBvesicle-associated membrane protein 3 (cellubrevin)-HPRD,BioGRID12130530 
VAMP4VAMP24vesicle-associated membrane protein 4Two-hybridBioGRID16189514 
VAMP7SYBL1 | TI-VAMP | VAMP-7vesicle-associated membrane protein 7Affinity Capture-WesternBioGRID12853575 
VAMP8EDBvesicle-associated membrane protein 8 (endobrevin)-HPRD,BioGRID10820264 
VAPBALS8 | VAMP-B | VAMP-C | VAP-B | VAP-CVAMP (vesicle-associated membrane protein)-associated protein B and CReconstituted ComplexBioGRID12651853 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 3825All SZGR genes in this pathway
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 4430All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_INSULIN_GLUCOSE_PATHWAY 2624All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_BOTULINUM_NEUROTOXICITY 1914All SZGR genes in this pathway
REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 6031All SZGR genes in this pathway
REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS 1712All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
NAKAMURA_METASTASIS 4728All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_UP 4526All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-199104110m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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