Gene Page: STXBP1

Summary
GeneID  6812
Symbol  STXBP1
Synonyms  EIEE4|MUNC18-1|UNC18|hUNC18|rbSec1
Description  syntaxin binding protein 1
See related  HGNC:11444|MIM:602926|Ensembl:ENSG00000136854|HPRD:04235|
Locus tag  RP11-56D16.3
Gene type  protein-coding
Map location  9q34.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0549 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006904vesicle docking during exocytosisIEA-
GO:0016192vesicle-mediated transportIEA-
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APBA1D9S411E | MINT1 | X11 | X11A | X11ALPHAamyloid beta (A4) precursor protein-binding, family A, member 1-HPRD9395480 
CDK5PSSALREcyclin-dependent kinase 5-HPRD,BioGRID12963086 
DOC2A-double C2-like domains, alpha-HPRD,BioGRID9115738 
DOC2B-double C2-like domains, beta-HPRD,BioGRID9115738 
MAPTDDPAC | FLJ31424 | FTDP-17 | MAPTL | MGC138549 | MSTD | MTBT1 | MTBT2 | PPND | TAUmicrotubule-associated protein tau-HPRD,BioGRID12963086 
NEFHNFHneurofilament, heavy polypeptide-HPRD12963086 
NEFMNEF3 | NF-M | NFMneurofilament, medium polypeptide-HPRD12963086 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDa-HPRD9395480 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)Affinity Capture-Western
Reconstituted Complex		BioGRID7553862 |7768895 
|10449403 |12093152 
|12963086 
-HPRD9045631 
STX1BSTX1B1 | STX1B2syntaxin 1BReconstituted ComplexBioGRID12093152 
STX2EPIM | EPM | MGC51014 | STX2A | STX2B | STX2Csyntaxin 2Affinity Capture-Western
Reconstituted Complex		BioGRID7768895 |12773094 
-HPRD9045631 
STX3STX3Asyntaxin 3-HPRD9045631 
Reconstituted ComplexBioGRID7768895 
STX4STX4A | p35-2syntaxin 4Affinity Capture-Western
Reconstituted Complex		BioGRID7768895 |12773094 
SYTL4DKFZp451P0116 | FLJ40960 | SLP4synaptotagmin-like 4Affinity Capture-WesternBioGRID12590134 
TUBA4AFLJ30169 | H2-ALPHA | TUBA1tubulin, alpha 4aAffinity Capture-WesternBioGRID12963086 
TUBB2ATUBB | TUBB2 | dJ40E16.7tubulin, beta 2AAffinity Capture-WesternBioGRID12963086 
USO1P115 | TAP | VDPUSO1 homolog, vesicle docking protein (yeast)-HPRD10903204 |11927603 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 1513All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 1111All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 109All SZGR genes in this pathway
REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 1010All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN 14184All SZGR genes in this pathway
HU_ANGIOGENESIS_UP 2116All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_UP 5340All SZGR genes in this pathway
ROSS_AML_WITH_PML_RARA_FUSION 7762All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
WANG_LSD1_TARGETS_DN 3930All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP 13995All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
VALK_AML_CLUSTER_12 3020All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-134125912651Ahsa-miR-134brainUGUGACUGGUUGACCAGAGGG
miR-141/200a17431749m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/49712251231m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-218176117681A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-410165916651Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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