Gene Page: SYP

Summary
GeneID  6855
Symbol  SYP
Synonyms  -
Description  synaptophysin
See related  HGNC:11506|MIM:313475|Ensembl:ENSG00000102003|HPRD:02435|
Locus tag  -
Gene type  protein-coding
Map location  Xp11.23-p11.22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
POLD20.940.95
PPP4C0.920.94
CLPP0.920.92
PTOV10.920.92
AP4M10.910.92
MIIP0.910.93
BCS1L0.910.92
GNB20.910.92
PRMT10.910.94
TSEN340.910.91
Top 10 negatively co-expressed genes
AF347015.27-0.71-0.82
AF347015.33-0.71-0.84
MT-CO2-0.69-0.80
MT-CYB-0.69-0.82
AF347015.8-0.69-0.82
AF347015.31-0.68-0.79
AF347015.15-0.68-0.82
AF347015.2-0.67-0.83
AF347015.26-0.66-0.83
HLA-F-0.64-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingNAS-
GO:0005515protein bindingNAS10620806 
GO:0005215transporter activityIEA-
GO:0015485cholesterol bindingIDA10620806 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016188synaptic vesicle maturationNASSynap (GO term level: 8)10620806 
GO:0048499synaptic vesicle membrane organizationNASSynap (GO term level: 5)10620806 
GO:0006810transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042734presynaptic membraneIEAneuron, axon, Synap (GO term level: 5)-
GO:0008021synaptic vesicleIEASynap, Neurotransmitter (GO term level: 12)-
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0030285integral to synaptic vesicle membraneNASSynap (GO term level: 14)1975480 
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0030054cell junctionIEA-
GO:0031410cytoplasmic vesicleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP1G1ADTG | CLAPG1 | MGC18255adaptor-related protein complex 1, gamma 1 subunitTwo-hybridBioGRID12498786 
EPORMGC138358erythropoietin receptorReconstituted ComplexBioGRID7534299 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-WesternBioGRID7534299 
SIAH1FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1seven in absentia homolog 1 (Drosophila)-HPRD,BioGRID11786535 
SIAH2hSiah2seven in absentia homolog 2 (Drosophila)-HPRD,BioGRID11786535 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)Affinity Capture-WesternBioGRID7553862 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN 6845All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN 8053All SZGR genes in this pathway
MIKKELSEN_ES_HCP_WITH_H3_UNMETHYLATED 6331All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED 228119All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-224355361m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-24164170m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.