Gene Page: MAP3K7

Summary
GeneID  6885
Symbol  MAP3K7
Synonyms  TAK1|TGF1a
Description  mitogen-activated protein kinase kinase kinase 7
See related  HGNC:6859|MIM:602614|Ensembl:ENSG00000135341|HPRD:04011|
Locus tag  -
Gene type  protein-coding
Map location  6q16.1-q16.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0024 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZBTB100.890.93
SPIRE10.890.94
IL17RD0.890.88
MED130.880.93
RCOR10.880.91
ZNF1920.870.88
CCNG20.870.90
BMPR1A0.870.90
RBM120.870.92
RBM150.870.91
Top 10 negatively co-expressed genes
AIFM3-0.65-0.74
FXYD1-0.63-0.84
S100B-0.63-0.80
AF347015.31-0.63-0.82
HLA-F-0.63-0.70
C5orf53-0.63-0.69
MT-CO2-0.62-0.83
TSC22D4-0.62-0.74
AF347015.27-0.62-0.79
AF347015.33-0.62-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004708MAP kinase kinase activityIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI15075345 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0004709MAP kinase kinase kinase activityTAS9466656 
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000165MAPKKK cascadeIEA-
GO:0001525angiogenesisIEA-
GO:0002726positive regulation of T cell cytokine productionIMP15125833 
GO:0001841neural tube formationIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007252I-kappaB phosphorylationIEA-
GO:0007250activation of NF-kappaB-inducing kinase activityIMP15125833 
GO:0007179transforming growth factor beta receptor signaling pathwayIEA-
GO:0007179transforming growth factor beta receptor signaling pathwayTAS9466656 
GO:0043066negative regulation of apoptosisIEA-
GO:0050852T cell receptor signaling pathwayNAS15125833 
GO:0050870positive regulation of T cell activationIC15125833 
GO:0032743positive regulation of interleukin-2 productionIMP15125833 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0046330positive regulation of JNK cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9162092 |9744859 |10066798 
|12609980 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1-HPRD14743216 
CAD-carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase-HPRD14743216 
CALM3PHKD | PHKD3calmodulin 3 (phosphorylase kinase, delta)-HPRD14743216 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)-HPRD14743216 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinase-HPRD,BioGRID10187861 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD14743216 
DARSDKFZp781B11202 | MGC111579aspartyl-tRNA synthetase-HPRD14743216 
DDX5DKFZp686J01190 | G17P1 | HLR1 | HUMP68 | p68DEAD (Asp-Glu-Ala-Asp) box polypeptide 5-HPRD14743216 
DNAJA1DJ-2 | DjA1 | HDJ2 | HSDJ | HSJ2 | HSPF4 | hDJ-2DnaJ (Hsp40) homolog, subfamily A, member 1-HPRD14743216 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingE2F4 interacts with MAP3K7 promoter.BIND15782160 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1-HPRD14743216 
ENO1ENO1L1 | MBP-1 | MPB1 | NNE | PPHenolase 1, (alpha)-HPRD14743216 
EPRSDKFZp313B047 | EARS | GLUPRORS | PARS | PIG32 | QARS | QPRSglutamyl-prolyl-tRNA synthetase-HPRD14743216 
FKBP5FKBP51 | FKBP54 | MGC111006 | P54 | PPIase | Ptg-10FK506 binding protein 5-HPRD14743216 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD14743216 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD11397816 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrate-HPRD,BioGRID11397816 
HIST1H4IH4/m | H4FM | H4Mhistone cluster 1, H4i-HPRD14743216 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD14743216 
HSP90AB1D6S182 | FLJ26984 | HSP90-BETA | HSP90B | HSPC2 | HSPCBheat shock protein 90kDa alpha (cytosolic), class B member 1-HPRD14743216 
HSPA1BFLJ54328 | HSP70-1B | HSP70-2 | HSPA1Aheat shock 70kDa protein 1B-HPRD14743216 
HSPA1LHSP70-1L | HSP70-HOM | HSP70T | hum70theat shock 70kDa protein 1-like-HPRD14743216 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD14743216 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
HSPA9CSA | GRP75 | HSPA9B | MGC4500 | MOT | MOT2 | MTHSP75 | PBP74 | mot-2heat shock 70kDa protein 9 (mortalin)-HPRD14743216 
IARSFLJ20736 | IARS1 | ILRS | PRO0785isoleucyl-tRNA synthetase-HPRD14743216 
MAP2K4JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1mitogen-activated protein kinase kinase 4-HPRD12556533 
MAP2K6MAPKK6 | MEK6 | MKK6 | PRKMK6 | SAPKK3mitogen-activated protein kinase kinase 6-HPRD,BioGRID11460167 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD,BioGRID10094049 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD,BioGRID10921914 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7Reconstituted ComplexBioGRID9556573 
MAP3K7IP13'-Tab1 | MGC57664 | TAB1mitogen-activated protein kinase kinase kinase 7 interacting protein 1-HPRD,BioGRID10838074 
An unspecified isoform of TAK1 interacts with TAB1. This interaction was modeled on a demonstrated interaction between TAK1 from an unspecified species and human TAB1.BIND9878061 
-HPRD10838074|14743216 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD,BioGRID11259596 
-HPRD11259596 |14743216 
MAP3K7IP3MGC45404 | NAP1 | TAB3mitogen-activated protein kinase kinase kinase 7 interacting protein 3Affinity Capture-WesternBioGRID14633987 |14670075 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1-HPRD,BioGRID10224067 
MAP4K4FLH21957 | FLJ10410 | FLJ20373 | FLJ90111 | HGK | KIAA0687 | NIKmitogen-activated protein kinase kinase kinase kinase 4-HPRD,BioGRID10807933 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD11865055 
NAIPBIRC1 | FLJ18088 | FLJ42520 | FLJ58811 | NLRB1 | psiNAIPNLR family, apoptosis inhibitory protein-HPRD11865055 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1-HPRD9556573 
NUDT21CFIM25 | CPSF5 | DKFZp686H1588nudix (nucleoside diphosphate linked moiety X)-type motif 21-HPRD14743216 
PEBP1HCNP | PBP | PEBP | RKIPphosphatidylethanolamine binding protein 1-HPRD,BioGRID11585904 
PELI3MGC35521pellino homolog 3 (Drosophila)-HPRD12874243 
PPM1BMGC21657 | PP2C-beta-X | PP2CB | PP2CBETA | PPC2BETAXprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform-HPRD,BioGRID11104763 
PPM1LMGC132545 | MGC132547 | PP2C-epsilon | PP2CE | PPM1-LIKEprotein phosphatase 1 (formerly 2C)-like-HPRD12556533 
RPLP0L10E | MGC111226 | MGC88175 | P0 | PRLP0 | RPP0ribosomal protein, large, P0-HPRD14743216 
RPS3FLJ26283 | FLJ27450 | MGC87870ribosomal protein S3-HPRD14743216 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)-HPRD14743216 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)-HPRD14743216 
SMAD6HsT17432 | MADH6 | MADH7SMAD family member 6-HPRD,BioGRID10748100 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7-HPRD,BioGRID12589052 
STRADBALS2CR2 | CALS-21 | ILPIP | ILPIPA | MGC102916 | PAPK | PRO1038STE20-related kinase adaptor beta-HPRD,BioGRID12048196 
TNFRSF11ACD265 | FEO | LOH18CR1 | ODFR | OFE | OPTB7 | OSTS | PDB2 | RANK | TRANCERtumor necrosis factor receptor superfamily, member 11a, NFKB activator-HPRD,BioGRID11809792 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2Affinity Capture-WesternBioGRID14633987 
-HPRD14743216 
TRAF3IP2ACT1 | C6orf2 | C6orf4 | C6orf5 | C6orf6 | CIKS | DKFZp586G0522 | MGC3581TRAF3 interacting protein 2-HPRD12089335 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD,BioGRID10094049 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
TUBB2ATUBB | TUBB2 | dJ40E16.7tubulin, beta 2A-HPRD14743216 
TUBB2BDKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1tubulin, beta 2B-HPRD14743216 
TUBB4TUBB5 | beta-5tubulin, beta 4-HPRD14743216 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosis-HPRD,BioGRID12048196 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_NTHI_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_NFKB_PATHWAY 2319All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY 3329All SZGR genes in this pathway
BIOCARTA_TGFB_PATHWAY 1914All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_TOLL_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_WNT_PATHWAY 2624All SZGR genes in this pathway
ST_TUMOR_NECROSIS_FACTOR_PATHWAY 2920All SZGR genes in this pathway
ST_P38_MAPK_PATHWAY 3728All SZGR genes in this pathway
ST_JNK_MAPK_PATHWAY 4030All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_P38_MKK3_6PATHWAY 2621All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY 3226All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
PID_TNF_PATHWAY 4633All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
PID_TCR_JNK_PATHWAY 1411All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY 3025All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_DOWNSTREAM_TCR_SIGNALING 3732All SZGR genes in this pathway
REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 2317All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 169All SZGR genes in this pathway
REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION 1812All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX 147All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_NOD1_2_SIGNALING_PATHWAY 3022All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 4633All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_DN 7351All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_UP 12171All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_DN 10359All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_DN 4524All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_6Q21_DELETION 2015All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_2_UP 1710All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 181101All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-104554621A,m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-103/1071281341Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-141/200a84901Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-1433994061A,m8hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-339454460m8hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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