Gene Page

Home
Datasets
Search
Analysis & Tools
Documents
About SZGR
Quick search: (e.g. 207 or AKT)

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

Release Site Map Support Contact us

Gene Page: TRAF3

Summary

GeneID

7187

Symbol

TRAF3

Synonyms

CAP-1|CD40bp|CRAF1|LAP1

Description

TNF receptor-associated factor 3

Locus tag

Gene type

protein-coding

Map location

14q32.32

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 1.706

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004871

signal transducer activity

TAS

7530216 |7533327

GO:0005515

protein binding

IPI

7527023 |9162022 |10791955
|11035039 |12005438
|15280356

GO:0008270

zinc ion binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006917

induction of apoptosis

TAS

10799510

GO:0007165

signal transduction

TAS

7530216

GO:0042981

regulation of apoptosis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	-	HPRD	11950878
CAP1	CAP \| CAP1-PEN	CAP, adenylate cyclase-associated protein 1 (yeast)	-	HPRD	8761950
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11261798
CD27	MGC20393 \| S152 \| T14 \| TNFRSF7 \| Tp55	CD27 molecule	-	HPRD,BioGRID	9582383 \|9794406
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	-	HPRD	7527023 \|7530216 \|7533327 \|10984535
			Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7527023 \|9384571 \|9990007 \|10984535
			CD40 interacts with TRAF3.	BIND	10352240
			-	HPRD	7527023 \|7533327 \|10984535
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	Affinity Capture-Western	BioGRID	10837247
EDA2R	EDA-A2R \| EDAA2R \| TNFRSF27 \| XEDAR	ectodysplasin A2 receptor	Affinity Capture-Western	BioGRID	12270937
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
LTBR	CD18 \| D12S370 \| LT-BETA-R \| TNF-R-III \| TNFCR \| TNFR-RP \| TNFR2-RP \| TNFRSF3	lymphotoxin beta receptor (TNFR superfamily, member 3)	-	HPRD,BioGRID	9122217
LTBR		lymphotoxin beta receptor (TNFR superfamily, member 3)	TRAF3 interacts with LTBR.	BIND	12571250
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	-	HPRD	8626767
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	11278268
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	NIK interacts with TRAF3. This interaction was modeled on a demonstrated interaction between human NIK and TRAF3 from an unspecified species.	BIND	9275204
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	Affinity Capture-Western	BioGRID	9774977
NGFR	CD271 \| Gp80-LNGFR \| TNFRSF16 \| p75(NTR) \| p75NTR	nerve growth factor receptor (TNFR superfamily, member 16)	Affinity Capture-Western	BioGRID	10514511
NUP62	DKFZp547L134 \| FLJ20822 \| FLJ43869 \| IBSN \| MGC841 \| SNDI \| p62	nucleoporin 62kDa	in vitro in vivo Two-hybrid	BioGRID	10781837
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD,BioGRID	8612133
RRAS2	TC21	related RAS viral (r-ras) oncogene homolog 2	-	HPRD	10557073
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western	BioGRID	10635328
TANK	I-TRAF \| TRAF2	TRAF family member-associated NFKB activator	-	HPRD,BioGRID	8710854
TNFRSF11A	CD265 \| FEO \| LOH18CR1 \| ODFR \| OFE \| OPTB7 \| OSTS \| PDB2 \| RANK \| TRANCER	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	-	HPRD,BioGRID	9774460 \|9852070 \|10025951
TNFRSF12A	CD266 \| FN14 \| TWEAKR	tumor necrosis factor receptor superfamily, member 12A	-	HPRD	11728344
TNFRSF14	ATAR \| HVEA \| HVEM \| LIGHTR \| TR2	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	-	HPRD,BioGRID	9162022
TNFRSF17	BCM \| BCMA \| CD269	tumor necrosis factor receptor superfamily, member 17	-	HPRD,BioGRID	10903733
TNFRSF18	AITR \| GITR \| GITR-D	tumor necrosis factor receptor superfamily, member 18	-	HPRD,BioGRID	10037686
TNFRSF19	TAJ \| TAJ-alpha \| TRADE \| TROY	tumor necrosis factor receptor superfamily, member 19	-	HPRD,BioGRID	10809768
TNFRSF4	ACT35 \| CD134 \| OX40 \| TXGP1L	tumor necrosis factor receptor superfamily, member 4	-	HPRD	9418902
TNFRSF8	CD30 \| D1S166E \| KI-1	tumor necrosis factor receptor superfamily, member 8	CRAF1 interacts with CD30.	BIND	8662842
TNFRSF8	CD30 \| D1S166E \| KI-1	tumor necrosis factor receptor superfamily, member 8	-	HPRD,BioGRID	8943059
TNFRSF9	4-1BB \| CD137 \| CDw137 \| ILA \| MGC2172	tumor necrosis factor receptor superfamily, member 9	-	HPRD,BioGRID	9464265
TNFSF14	CD258 \| HVEML \| LIGHT \| LTg \| TR2	tumor necrosis factor (ligand) superfamily, member 14	Affinity Capture-MS Affinity Capture-Western	BioGRID	12571250
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	8565075
TRAF3IP1	DKFZp434F124 \| MIP-T3 \| MIPT3	TNF receptor-associated factor 3 interacting protein 1	-	HPRD,BioGRID	10791955
TRAF3IP2	ACT1 \| C6orf2 \| C6orf4 \| C6orf5 \| C6orf6 \| CIKS \| DKFZp586G0522 \| MGC3581	TRAF3 interacting protein 2	-	HPRD,BioGRID	12089335
TRAF3IP3	DJ434O14.3 \| FLJ44151 \| MGC117354 \| MGC163289 \| T3JAM	TRAF3 interacting protein 3	-	HPRD	14572659
TRIM37	KIAA0898 \| MUL \| POB1 \| TEF3	tripartite motif-containing 37	-	HPRD,BioGRID	11279055
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	Affinity Capture-Western	BioGRID	10764746
USP7	HAUSP \| TEF1	ubiquitin specific peptidase 7 (herpes virus-associated)	-	HPRD,BioGRID	11279055

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	102	88	All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY	71	51	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER	84	67	All SZGR genes in this pathway
BIOCARTA_CD40_PATHWAY	15	13	All SZGR genes in this pathway
BIOCARTA_TALL1_PATHWAY	15	15	All SZGR genes in this pathway
BIOCARTA_TNFR2_PATHWAY	18	15	All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY	32	25	All SZGR genes in this pathway
SIG_CD40PATHWAYMAP	34	28	All SZGR genes in this pathway
PID_CD40_PATHWAY	31	26	All SZGR genes in this pathway
REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	14	10	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON	14	7	All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING	31	19	All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS	73	57	All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM	279	178	All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING	93	69	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES	118	84	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP	206	111	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN	460	312	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN	50	36	All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	1278	748	All SZGR genes in this pathway
KIM_WT1_TARGETS_UP	214	155	All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP	55	40	All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP	536	340	All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2	127	92	All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP	69	55	All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_2	30	23	All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN	77	49	All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_UP	53	35	All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS	183	115	All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP	77	52	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP	225	139	All SZGR genes in this pathway
ZHANG_RESPONSE_TO_CANTHARIDIN_UP	19	12	All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN	52	33	All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP	37	31	All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP	77	57	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2	473	224	All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP	156	92	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN	249	165	All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING	510	309	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP	338	225	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP	418	282	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP	408	276	All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1	237	159	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN	321	200	All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A	770	480	All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38	337	236	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-25/32/92/363/367	461	467	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-494	470	476	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.