Gene Page

Gene Page: TTC1

Summary

GeneID

7265

Symbol

TTC1

Synonyms

FLJ46404|TPR1

Description

tetratricopeptide repeat domain 1

Locus tag

Gene type

protein-coding

Map location

5q33.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0032

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.01718

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00459

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0393

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0051082

unfolded protein binding

TAS

8836031

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006457

protein folding

TAS

8836031

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACY1	ACY1D \| ACYLASE	aminoacylase 1	Two-hybrid	BioGRID	16189514
CRY2	FLJ10332 \| HCRY2 \| KIAA0658 \| PHLL2	cryptochrome 2 (photolyase-like)	Two-hybrid	BioGRID	9383998
DNAJB1	HSPF1 \| Hdj1 \| Hsp40 \| Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	-	HPRD	14503850
GNA15	GNA16	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	-	HPRD,BioGRID	12748287
GNA15	GNA16		G-alpha-16 interacts with TPR1	BIND	12748287
GNAI2	GIP \| GNAI2B \| H_LUCA15.1 \| H_LUCA16.1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	-	HPRD,BioGRID	12748287
GNAQ	G-ALPHA-q \| GAQ	guanine nucleotide binding protein (G protein), q polypeptide	G-alpha-q interacts with TPR1.	BIND	12748287
GNAQ	G-ALPHA-q \| GAQ		-	HPRD,BioGRID	12748287
GNAS	AHO \| C20orf45 \| GNAS1 \| GPSA \| GSA \| GSP \| MGC33735 \| PHP1A \| PHP1B \| POH \| dJ309F20.1.1 \| dJ806M20.3.3	GNAS complex locus	G-alpha-s-Short interacts with TPR1.	BIND	12748287
			-	HPRD,BioGRID	12748287
			G-alpha-s-Long interacts with TPR1.	BIND	12748287
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD,BioGRID	12748287
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD	14503850
HSPA4	APG-2 \| HS24/P52 \| MGC131852 \| RY \| hsp70 \| hsp70RY	heat shock 70kDa protein 4	Affinity Capture-Western Reconstituted Complex	BioGRID	14503850

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
MULLIGHAN_MLL_SIGNATURE_1_UP	380	236	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN	167	100	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP	557	331	All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP	239	157	All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP	584	356	All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5	147	89	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN	584	395	All SZGR genes in this pathway
STONER_ESOPHAGEAL_CARCINOGENESIS_UP	39	25	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
MOOTHA_PGC	420	269	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
NIELSEN_GIST	98	66	All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	756	494	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL	129	85	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	898	516	All SZGR genes in this pathway