Gene Page: TTR

Summary
GeneID  7276
Symbol  TTR
Synonyms  HsT2651|PALB|TBPA
Description  transthyretin
See related  HGNC:12405|MIM:176300|Ensembl:ENSG00000118271|HPRD:01447|
Locus tag  -
Gene type  protein-coding
Map location  18q12.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.3333 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COMMD90.810.80
PRKAG10.800.76
GABARAPL20.800.80
COPS40.790.75
ARPC40.790.76
UBE2D20.780.77
ATP5B0.780.75
UBE2E10.770.77
FAM54B0.770.73
POP40.770.73
Top 10 negatively co-expressed genes
AF347015.18-0.64-0.62
AF347015.2-0.62-0.53
AF347015.8-0.62-0.53
AF347015.26-0.61-0.54
MT-ATP8-0.57-0.51
AF347015.15-0.57-0.49
MT-CYB-0.57-0.49
AC100783.1-0.57-0.57
MT-CO2-0.56-0.47
AC016705.1-0.55-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0005496steroid bindingIEA-
GO:0019841retinol bindingIEA-
GO:0016918retinal bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006810transportNAS10841549 
GO:0006590thyroid hormone generationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF4CREB-2 | CREB2 | TAXREB67 | TXREBactivating transcription factor 4 (tax-responsive enhancer element B67)Two-hybridBioGRID16189514 
C7orf20CEE | CGI-20chromosome 7 open reading frame 20Two-hybridBioGRID16169070 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3Two-hybridBioGRID16169070 
DDR1CAK | CD167 | DDR | EDDR1 | MCK10 | NEP | NTRK4 | PTK3 | PTK3A | RTK6 | TRKEdiscoidin domain receptor tyrosine kinase 1Two-hybridBioGRID16169070 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1Two-hybridBioGRID16169070 
FEZ1-fasciculation and elongation protein zeta 1 (zygin I)Two-hybridBioGRID16169070 
HNRNPH32H9 | FLJ34092 | HNRPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)Two-hybridBioGRID16169070 
HSPG2PLC | PRCAN | SJA | SJS | SJS1heparan sulfate proteoglycan 2-HPRD,BioGRID9307034 
IKBKAPDKFZp781H1425 | DYS | ELP1 | FD | FLJ12497 | IKAP | IKI3 | TOT1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated proteinTwo-hybridBioGRID16169070 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD10982792 
MARK3CTAK1 | KP78 | PAR1AMAP/microtubule affinity-regulating kinase 3Two-hybridBioGRID16169070 
PHYHIPDYRK1AP3 | KIAA0273 | PAHX-AP | PAHXAP1phytanoyl-CoA 2-hydroxylase interacting proteinTwo-hybridBioGRID16169070 
RBP4-retinol binding protein 4, plasma-HPRD,BioGRID574085 |8089102 
|11853533 |12593674 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1Two-hybridBioGRID16169070 
TTRHsT2651 | PALB | TBPAtransthyretinCo-crystal StructureBioGRID11243784 
VIMFLJ36605vimentinTwo-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_HNF3B_PATHWAY 4537All SZGR genes in this pathway
REACTOME_AMYLOIDS 8363All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
KONDO_HYPOXIA 86All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_UP 4936All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
WONG_IFNA2_RESISTANCE_DN 3420All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_DN 1711All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
LEE_LIVER_CANCER 4929All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_DN 6435All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_DN 7043All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
SASAI_TARGETS_OF_CXCR6_AND_PTCH1_UP 139All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_DN 11376All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
VANDESLUIS_COMMD1_TARGETS_GROUP_4_UP 1912All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a7884m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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