Gene Page: UROS

Summary
GeneID  7390
Symbol  UROS
Synonyms  -
Description  uroporphyrinogen III synthase
See related  HGNC:12592|MIM:606938|Ensembl:ENSG00000188690|HPRD:06087|
Locus tag  RP11-124H7.1
Gene type  protein-coding
Map location  10q25.2-q26.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03487 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MICAL20.940.78
EXTL10.930.87
MFSD40.930.82
KCNIP30.930.90
TYRO30.920.75
TMEM38A0.920.88
KCNK10.910.87
PACSIN10.910.88
TOLLIP0.910.74
CAMK2A0.910.88
Top 10 negatively co-expressed genes
FADS2-0.55-0.61
BCL7C-0.55-0.72
TUBB2B-0.53-0.69
PDE9A-0.53-0.69
KIAA1949-0.53-0.62
TRAF4-0.53-0.70
PKN1-0.52-0.64
SH3BP2-0.52-0.67
HEBP2-0.52-0.80
GPR125-0.52-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004852uroporphyrinogen-III synthase activityIEA-
GO:0016829lyase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008152metabolic processIEA-
GO:0006783heme biosynthetic processIEA-
GO:0006780uroporphyrinogen III biosynthetic processTAS2331520 
GO:0006779porphyrin biosynthetic processIEA-
GO:0033014tetrapyrrole biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
UROS-uroporphyrinogen III synthase-HPRD11689424 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM 4123All SZGR genes in this pathway
BIOCARTA_AHSP_PATHWAY 136All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PORPHYRINS 147All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN 5437All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
WELCH_GATA1_TARGETS 2212All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP 4030All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL 12985All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway


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