Gene Page: XRCC1

Summary
GeneID  7515
Symbol  XRCC1
Synonyms  RCC
Description  X-ray repair complementing defective repair in Chinese hamster cells 1
See related  HGNC:12828|MIM:194360|Ensembl:ENSG00000073050|HPRD:01909|
Locus tag  -
Gene type  protein-coding
Map location  19q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003684damaged DNA bindingIEA-
GO:0005515protein bindingIPI14755728 |15044383 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000012single strand break repairIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP8978692 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APEX1APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1APEX nuclease (multifunctional DNA repair enzyme) 1-HPRD,BioGRID11707423 
APTXAOA | AOA1 | AXA1 | EAOH | EOAHA | FHA-HIT | FLJ20157 | MGC1072aprataxinAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID15044383 |15555565 
APTX interacts with XRCC1.BIND15555565 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD11352725 
LIG3LIG2ligase III, DNA, ATP-dependent-HPRD,BioGRID8264637 |9136882 
|9705932 |11163244 
NEIL1FLJ22402 | FPG1 | NEI1 | hFPG1nei endonuclease VIII-like 1 (E. coli)XRCC1 interacts with Neil1.BIND15260972 
-HPRD,BioGRID15260972 
OGG1HMMH | HOGG1 | MUTM | OGH18-oxoguanine DNA glycosylaseReconstituted Complex
Two-hybrid		BioGRID12933815 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9584196 |15044383 
-HPRD9584196 |14500814 
PARP2ADPRT2 | ADPRTL2 | ADPRTL3 | PARP-2 | pADPRT-2poly (ADP-ribose) polymerase 2Affinity Capture-WesternBioGRID11948190 
PCNAMGC8367proliferating cell nuclear antigenAffinity Capture-Western
Co-localization
FRET
Reconstituted Complex		BioGRID15107487 
PNKPPNKpolynucleotide kinase 3'-phosphataseAffinity Capture-MS
Affinity Capture-Western
Far Western
Two-hybrid		BioGRID11163244 |17353931 
Phosphorylated XRCC1 interacts with PNK.BIND15066279 
POLBMGC125976polymerase (DNA directed), beta-HPRD,BioGRID8978692 |11467963 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-WesternBioGRID15044383 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_BASE_EXCISION_REPAIR 3522All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
REACTOME_BASE_EXCISION_REPAIR 1913All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 127All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_3 4831All SZGR genes in this pathway
HEIDENBLAD_AMPLICON_8Q24_DN 4628All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
AMUNDSON_GAMMA_RADIATION_RESISTANCE 2014All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway


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