Gene Page: CALCA

Summary
GeneID  796
Symbol  CALCA
Synonyms  CALC1|CGRP|CGRP-I|CGRP1|CT|KC|MGC126648
Description  calcitonin-related polypeptide alpha
See related  HGNC:1437|MIM:114130|Ensembl:ENSG00000110680|HPRD:00238|
Locus tag  -
Gene type  protein-coding
Map location  11p15.2-p15.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GOLIM40.810.83
COBLL10.780.79
TLN10.750.81
PTRF0.730.76
CGNL10.720.78
FYCO10.720.82
COL14A10.710.73
GIMAP80.710.74
MYH110.710.71
FAM129A0.700.73
Top 10 negatively co-expressed genes
ZNF32-0.49-0.59
COMMD3-0.47-0.56
NDUFAF2-0.47-0.55
PFDN5-0.47-0.59
PHPT1-0.46-0.57
OXSM-0.46-0.54
C11orf73-0.46-0.54
MRPS24-0.46-0.50
AC034193.4-0.46-0.50
DCTN3-0.46-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0031716calcitonin receptor bindingIEA-
GO:0031716calcitonin receptor bindingIPI8078488 |8940110 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007218neuropeptide signaling pathwayIEANeurotransmitter (GO term level: 8)-
GO:0001984vasodilation of artery during baroreceptor response to increased systemic arterial blood pressureIEA-
GO:0002027regulation of heart rateIEA-
GO:0001944vasculature developmentIDA17267696 
GO:0001935endothelial cell proliferationIDA17267696 
GO:0001976regulation of systemic arterial blood pressure by neurological processIDA10642343 
GO:0007190activation of adenylate cyclase activityIDA10822112 |16014619 
GO:0007267cell-cell signalingTAS2408883 
GO:0009408response to heatIEA-
GO:0007631feeding behaviorIEA-
GO:0007566embryo implantationIDA17983652 
GO:0006954inflammatory responseIEA-
GO:0007159leukocyte adhesionIDA1326102 
GO:0016481negative regulation of transcriptionIDA11014233 
GO:0050965detection of temperature stimulus involved in sensory perception of painIEA-
GO:0032757positive regulation of interleukin-8 productionIDA16904178 
GO:0032730positive regulation of interleukin-1 alpha productionIDA16904178 
GO:0048265response to painIEA-
GO:0030279negative regulation of ossificationIEA-
GO:0031645negative regulation of neurological system processIEA-
GO:0032147activation of protein kinase activityIDA17983652 
GO:0045779negative regulation of bone resorptionIDA10822112 |17241109 
GO:0045778positive regulation of ossificationIEA-
GO:0045651positive regulation of macrophage differentiationIDA10822112 
GO:0045762positive regulation of adenylate cyclase activityIDA8078488 |11014233 
GO:0045909positive regulation of vasodilationIDA3266556 
GO:0045671negative regulation of osteoclast differentiationIDA10822112 
GO:0043542endothelial cell migrationIDA17267696 
GO:0045986negative regulation of smooth muscle contractionIEA-
GO:0045776negative regulation of blood pressureIDA10642343 
GO:0051480cytosolic calcium ion homeostasisIDA9685362 
GO:0051482elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IDA8078488 |9685362 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0043195terminal buttonIEAaxon, Synap, Neurotransmitter (GO term level: 8)-
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA2408883 |18057382 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIDA17267696 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALCRCRT | CTR | CTR1calcitonin receptorCT interacts with CTR.BIND15155765 
CALCRLCGRPR | CRLRcalcitonin receptor-like-HPRD12234182 
-HPRD3001670 |8626685 
|9620797 |14668209 
RAMP1-receptor (G protein-coupled) activity modifying protein 1-HPRD12234182 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_AMYLOIDS 8363All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA 10358All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN 5745All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_DN 4328All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
KOHOUTEK_CCNT2_TARGETS 5835All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-488247253m8hsa-miR-488CCCAGAUAAUGGCACUCUCAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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