Gene Page: CAMK2D

Summary
GeneID  817
Symbol  CAMK2D
Synonyms  CAMKD|DKFZp686G23119|DKFZp686I2288|MGC44911
Description  calcium/calmodulin-dependent protein kinase II delta
See related  HGNC:1462|MIM:607708|Ensembl:ENSG00000145349|HPRD:09653|
Locus tag  -
Gene type  protein-coding
Map location  4q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0238 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
XPOT0.900.90
GFM10.890.90
APPBP20.890.91
MUDENG0.890.88
CLCN30.890.90
MUT0.890.89
ACTR20.880.90
COPB20.880.88
FAM91A10.880.89
HSPA90.880.88
Top 10 negatively co-expressed genes
AF347015.21-0.62-0.52
MT-CO2-0.58-0.56
CSAG1-0.57-0.54
FXYD1-0.57-0.55
HIGD1B-0.57-0.55
IFI27-0.56-0.56
AL022328.1-0.56-0.59
CXCL14-0.55-0.55
AF347015.31-0.54-0.55
IL32-0.54-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004683calmodulin-dependent protein kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthNAS9060999 
GO:0006468protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005954calcium- and calmodulin-dependent protein kinase complexTAS11264466 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alphaAffinity Capture-MSBioGRID17353931 
CD5LEU1 | T1CD5 moleculein vitro
Two-hybrid		BioGRID9692886 
RPS18D6S218E | HKE3 | KE-3 | KE3 | MGC117351 | MGC126835 | MGC126837ribosomal protein S18Affinity Capture-WesternBioGRID12145273 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_OLFACTORY_TRANSDUCTION 38985All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_CACAM_PATHWAY 1611All SZGR genes in this pathway
BIOCARTA_PGC1A_PATHWAY 2620All SZGR genes in this pathway
BIOCARTA_STATHMIN_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY 2725All SZGR genes in this pathway
ST_WNT_CA2_CYCLIC_GMP_PATHWAY 2014All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR 1715All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 3732All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 2723All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 3328All SZGR genes in this pathway
REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION 1514All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII 1514All SZGR genes in this pathway
REACTOME_INTERFERON_GAMMA_SIGNALING 6348All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
WANG_CLIM2_TARGETS_DN 186114All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
HU_ANGIOGENESIS_UP 2116All SZGR genes in this pathway
RODRIGUES_NTN1_AND_DCC_TARGETS 3525All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_DIRECT_UP 2721All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN 264168All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_DN 7043All SZGR genes in this pathway
MIKKELSEN_PLURIPOTENT_STATE_DN 87All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
SUZUKI_CTCFL_TARGETS_UP 125All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1456186251A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-185194719541A,m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-27174117471Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p1701771A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-31203120381A,m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-361164816551A,m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-4948490m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-505188118881A,m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
hsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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