Gene Page: PIP5K1A

Summary
GeneID  8394
Symbol  PIP5K1A
Synonyms  -
Description  phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
See related  HGNC:8994|MIM:603275|Ensembl:ENSG00000143398|
Locus tag  RP11-68I18.9
Gene type  protein-coding
Map location  1q22-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SEL1L0.940.96
NF10.940.95
C11orf410.940.95
MTOR0.930.96
MGAT50.930.96
PLEKHM30.930.96
ASH1L0.930.94
UBE4A0.930.95
MEGF90.930.95
PIKFYVE0.930.94
Top 10 negatively co-expressed genes
AF347015.31-0.66-0.70
FXYD1-0.66-0.68
AF347015.21-0.66-0.73
HIGD1B-0.65-0.71
C1orf54-0.65-0.78
MT-CO2-0.64-0.69
ENHO-0.63-0.69
SAT1-0.63-0.70
S100A16-0.62-0.66
TLCD1-0.62-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016740transferase activityIEA-
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activityNAS-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS8955136 
GO:0006650glycerophospholipid metabolic processTAS8955136 
GO:0016310phosphorylationNAS-
GO:0046488phosphatidylinositol metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012505endomembrane systemIEA-
GO:0005794Golgi apparatusIEA-
GO:0005575cellular_componentND-
GO:0005886plasma membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARF1-ADP-ribosylation factor 1-HPRD10589680 |10747863 
ARF5-ADP-ribosylation factor 5-HPRD10589680 
ARF6DKFZp564M0264ADP-ribosylation factor 6-HPRD10589680 
PIP5KL1MGC46424 | PIPKH | bA203J24.5phosphatidylinositol-4-phosphate 5-kinase-like 1Affinity Capture-WesternBioGRID14701839 
PLD1-phospholipase D1, phosphatidylcholine-specific-HPRD11032811 
PLD2-phospholipase D2-HPRD11032811 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INOSITOL_PHOSPHATE_METABOLISM 5442All SZGR genes in this pathway
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 7656All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_ARF6_DOWNSTREAM_PATHWAY 1514All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY 2119All SZGR genes in this pathway
PID_ARF_3PATHWAY 1913All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_DN 5835All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
YANAGIHARA_ESX1_TARGETS 3019All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
WEI_MIR34A_TARGETS 14897All SZGR genes in this pathway
AMIT_EGF_RESPONSE_40_HELA 4229All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_60_MCF10A 5742All SZGR genes in this pathway
HANSON_HRAS_SIGNALING_VIA_NFKB 2214All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_UP 7353All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
SASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN 86All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-34/4498398461A,m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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