Gene Page: CUL3

Summary
GeneID  8452
Symbol  CUL3
Synonyms  -
Description  cullin 3
See related  HGNC:2553|MIM:603136|Ensembl:ENSG00000036257|HPRD:09123|
Locus tag  -
Gene type  protein-coding
Map location  2q36.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FBXW20.930.94
SFRS140.930.94
USP480.920.93
NFX10.910.94
BRWD20.910.93
TTC170.910.94
ZC3H7A0.910.92
KIAA05280.900.93
MCM3AP0.900.92
TTC370.900.92
Top 10 negatively co-expressed genes
AF347015.31-0.82-0.86
MT-CO2-0.81-0.85
FXYD1-0.81-0.84
AF347015.27-0.79-0.83
AF347015.33-0.79-0.81
IFI27-0.78-0.84
AF347015.8-0.78-0.85
HIGD1B-0.78-0.85
MT-CYB-0.77-0.82
AF347015.21-0.77-0.86
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12609982 
GO:0031625ubiquitin protein ligase bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleTAS8681378 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0007050cell cycle arrestTAS8681378 
GO:0008284positive regulation of cell proliferationTAS9733711 
GO:0008629induction of apoptosis by intracellular signalsTAS8681378 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0005634nucleusIEA-
GO:0031461cullin-RING ubiquitin ligase complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAND1DKFZp434M1414 | FLJ10114 | FLJ10929 | FLJ38691 | FLJ90441 | KIAA0829 | TIP120 | TIP120Acullin-associated and neddylation-dissociated 1Affinity Capture-MS
Affinity Capture-Western		BioGRID12609982 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1-HPRD10500095 
CCNE1CCNEcyclin E1-HPRD,BioGRID10500095 
GPS1COPS1 | CSN1 | MGC71287G protein pathway suppressor 1-HPRD11337588 
NEDD8FLJ43224 | MGC104393 | MGC125896 | MGC125897 | Nedd-8neural precursor cell expressed, developmentally down-regulated 8-HPRD10500095 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1-HPRD11311237 
Affinity Capture-MSBioGRID12481031 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
PID_AURORA_B_PATHWAY 3924All SZGR genes in this pathway
PID_WNT_CANONICAL_PATHWAY 2018All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_DN 2513All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
KARAKAS_TGFB1_SIGNALING 1815All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C2 5439All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_UP 8448All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/301555561m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-137109911061A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1392022081Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-14013031309m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-141/200a351357m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-181238244m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-218907913m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-22873879m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-232342411A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/367102610321Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-299-3p148214881Ahsa-miR-299-3pUAUGUGGGAUGGUAAACCGCUU
miR-3232342401Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3817757811Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-493-5p7317371Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-543133813441Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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