Gene Page: TCAP

Summary
GeneID  8557
Symbol  TCAP
Synonyms  CMD1N|LGMD2G|T-cap|TELE|telethonin
Description  titin-cap (telethonin)
See related  HGNC:11610|MIM:604488|Ensembl:ENSG00000173991|HPRD:05133|
Locus tag  -
Gene type  protein-coding
Map location  17q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PHLDB20.470.47
ABCA90.440.46
APC0.420.35
NOV0.420.34
LAMC30.410.38
SLC6A200.400.38
PCDH200.400.34
GLT8D20.400.29
RECK0.400.37
APOB0.390.35
Top 10 negatively co-expressed genes
SSR4-0.25-0.26
RPS21-0.24-0.28
POLR2J-0.24-0.26
MRPL53-0.24-0.25
RPL23A-0.24-0.22
LSM2-0.23-0.24
NUDT8-0.23-0.25
AP003068.3-0.23-0.24
C22orf32-0.23-0.23
UXT-0.23-0.25
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI10984498 |11842093 
GO:0008307structural constituent of muscleTAS9350988 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyTAS9817758 
GO:0006950response to stressTAS17921333 
GO:0050982detection of mechanical stimulusTAS17921333 
GO:0045214sarcomere organizationTAS17921333 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0030018Z discIDA17921333 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANKRD2ARPP | MGC104314ankyrin repeat domain 2 (stretch responsive muscle)-HPRD,BioGRID15136035 
MSTNGDF8myostatin-HPRD12209887 
MYOZ1CS-2 | FATZ | MYOZmyozenin 1FATZ interacts with TELE.BIND10984498 
-HPRD,BioGRID10984498 
MYOZ2C4orf5 | CS-1myozenin 2Affinity Capture-WesternBioGRID11842093 
MYOZ3CS-3 | CS3 | FRP3myozenin 3-HPRD,BioGRID11842093 
TRIM55MURF-2 | RNF29tripartite motif-containing 55MURF-2 interacts with T-cap.BIND15967462 
TTNCMD1G | CMH9 | CMPD4 | CONNECTIN | DKFZp451N061 | EOMFC | FLJ26020 | FLJ26409 | FLJ32040 | FLJ34413 | FLJ39564 | FLJ43066 | HMERF | LGMD2J | TMDtitin-HPRD,BioGRID9645487 |9804419 
|9817758 |12446666 
Titin interacts with telethonin. This interaction was modelled on a demonstrated interaction between human Titin and telethonin from unspecified species.BIND15802564 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_STRIATED_MUSCLE_CONTRACTION 2712All SZGR genes in this pathway
REACTOME_MUSCLE_CONTRACTION 4824All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON 13378All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_UP 2923All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP 10369All SZGR genes in this pathway
SCHLINGEMANN_SKIN_CARCINOGENESIS_TPA_DN 2915All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway


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