Gene Page: UNC5C

Summary
GeneID  8633
Symbol  UNC5C
Synonyms  UNC5H3
Description  unc-5 homolog C (C. elegans)
See related  HGNC:12569|MIM:603610|Ensembl:ENSG00000182168|HPRD:04678|
Locus tag  -
Gene type  protein-coding
Map location  4q21-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DEDD0.960.95
FTSJ10.940.95
TINF20.940.93
DHPS0.940.94
PRR30.940.94
DDOST0.940.93
ARMC60.940.95
RPUSD40.940.94
C4orf140.930.92
EIF4A10.930.93
Top 10 negatively co-expressed genes
AF347015.27-0.78-0.90
AF347015.31-0.78-0.89
MT-CO2-0.78-0.89
AF347015.33-0.77-0.89
AF347015.8-0.77-0.91
MT-CYB-0.76-0.90
AF347015.15-0.74-0.89
AF347015.26-0.73-0.91
C5orf53-0.73-0.79
AIFM3-0.73-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005042netrin receptor activityTAS9782087 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentTASBrain (GO term level: 7)9782087 
GO:0007411axon guidanceTASaxon (GO term level: 13)9126742 
GO:0007165signal transductionIEA-
GO:0006915apoptosisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030334regulation of cell migrationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DAPK1DAPK | DKFZp781I035death-associated protein kinase 1UNC5C (UNC5H3) interacts with DAPK1 (DAPK). This interaction was modelled on a demonstrated interaction between rat UNC5H3 and human DAPK.BIND15729359 
NTN1NTN1Lnetrin 1-HPRD12810718 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_NETRIN_PATHWAY 3227All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING 4130All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_UP 5438All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/3515956011Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-30-5p3663731A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-324-5p3863931A,m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-3393823891A,m8hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-3842943011A,m8hsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-4862742811A,m8hsa-miR-486UCCUGUACUGAGCUGCCCCGAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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