Gene Page: EIF3H

Summary
GeneID  8667
Symbol  EIF3H
Synonyms  EIF3S3|MGC102958|eIF3-gamma|eIF3-p40
Description  eukaryotic translation initiation factor 3, subunit H
See related  HGNC:3273|MIM:603912|Ensembl:ENSG00000147677|HPRD:04885|
Locus tag  -
Gene type  protein-coding
Map location  8q24.11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0287 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MRPL170.790.78
PPP1CA0.770.71
C3orf750.770.74
HAX10.760.74
ZNF5110.760.71
MRPS70.750.74
MRPS110.750.71
STOML20.750.77
GABARAPL20.750.72
C11orf590.750.74
Top 10 negatively co-expressed genes
AF347015.18-0.44-0.37
AC010300.1-0.42-0.49
MT-ATP8-0.39-0.28
AC100783.1-0.39-0.34
AC016705.1-0.39-0.36
AF347015.26-0.37-0.28
AF347015.8-0.36-0.26
C10orf108-0.35-0.33
AF347015.2-0.35-0.24
AF347015.15-0.34-0.25
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003743translation initiation factor activityIEA-
GO:0005515protein bindingIPI12812986 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006446regulation of translational initiationTAS9341143 
GO:0006412translationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12588972 
GO:0005852eukaryotic translation initiation factor 3 complexTAS9341143 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI3NESH | SSH3BP3ABI family, member 3Two-hybridBioGRID16189514 
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1DISC-1 interacts with EIF3.BIND12812986 
Two-hybridBioGRID12812986 
EIF1BGC20eukaryotic translation initiation factor 1BAffinity Capture-MSBioGRID17353931 
EIF3AEIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185eukaryotic translation initiation factor 3, subunit AAffinity Capture-MS
Co-purification		BioGRID14519125 |17353931 
EIF3GEIF3-P42 | EIF3S4 | eIF3-delta | eIF3-p44eukaryotic translation initiation factor 3, subunit G-HPRD,BioGRID9822659 
EIF3KARG134 | EIF3-p28 | EIF3S12 | HSPC029 | M9 | MSTP001 | PLAC-24 | PLAC24 | PRO1474 | PTD001eukaryotic translation initiation factor 3, subunit K-HPRD14519125 
EIF4A2BM-010 | DDX2B | EIF4A | EIF4Feukaryotic translation initiation factor 4A, isoform 2Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSLATION 22275All SZGR genes in this pathway
REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 7424All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 8430All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 17651All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON 15787All SZGR genes in this pathway
DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER 10062All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
NOUZOVA_TRETINOIN_AND_H4_ACETYLATION 14385All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7 9863All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
BILANGES_SERUM_AND_RAPAMYCIN_SENSITIVE_GENES 6835All SZGR genes in this pathway
BILANGES_SERUM_RESPONSE_TRANSLATION 3720All SZGR genes in this pathway


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