Gene Page: RIPK2

Summary
GeneID  8767
Symbol  RIPK2
Synonyms  CARD3|CARDIAK|CCK|GIG30|RICK|RIP2
Description  receptor-interacting serine-threonine kinase 2
See related  HGNC:10020|MIM:603455|Ensembl:ENSG00000104312|HPRD:04585|
Locus tag  WUGSC:H_RG437L15.1
Gene type  protein-coding
Map location  8q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0259 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KDM2A0.930.94
BICD20.930.95
PRDM150.910.93
RAPGEF10.910.92
TGFBRAP10.910.92
TSC10.910.93
SIPA1L30.910.93
NCOR10.910.92
ZNF2360.900.93
HERC20.900.92
Top 10 negatively co-expressed genes
AF347015.31-0.72-0.76
HIGD1B-0.70-0.76
MT-CO2-0.69-0.75
C1orf54-0.69-0.83
AF347015.21-0.68-0.80
FXYD1-0.68-0.70
IFI27-0.66-0.68
AF347015.27-0.66-0.70
AF347015.33-0.65-0.67
MT-CYB-0.65-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0004871signal transducer activityTAS9642260 
GO:0030274LIM domain bindingIPI15657077 
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityEXP17468049 
GO:0004674protein serine/threonine kinase activityTAS9642260 
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
GO:0050700CARD domain bindingIPI11087742 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS9642260 
GO:0006954inflammatory responseTAS9705938 
GO:0043065positive regulation of apoptosisIEA-
GO:0042098T cell proliferationIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP17468049 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BIRC2API1 | HIAP2 | Hiap-2 | MIHB | RNF48 | cIAP1baculoviral IAP repeat-containing 2-HPRD,BioGRID9642260 
BIRC3AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49baculoviral IAP repeat-containing 3Affinity Capture-WesternBioGRID9705938 
CARD16COP | COP1 | PSEUDO-ICEcaspase recruitment domain family, member 16-HPRD11432859 |11536016 
-HPRD11432859 
CARD6CINCIN1caspase recruitment domain family, member 6-HPRD,BioGRID12775719 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD,BioGRID9705938 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD9575181 
CD40Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50CD40 molecule, TNF receptor superfamily member 5-HPRD,BioGRID9642260 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulator-HPRD,BioGRID9575181 
COPCLTOclathrin-ordered proteinAffinity Capture-WesternBioGRID11432859 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma-HPRD,BioGRID10880512 
KCTD12C13orf2 | FLJ33073 | KIAA1778 | PFET1 | PFETINpotassium channel tetramerisation domain containing 12Affinity Capture-MSBioGRID17353931 
NOD1CARD4 | CLR7.1 | NLRC1nucleotide-binding oligomerization domain containing 1Nod1 interacts with, and enhances RICK activity.BIND10329646 
-HPRD,BioGRID10329646 
NOD2ACUG | BLAU | CARD15 | CD | CLR16.3 | IBD1 | NLRC2 | NOD2B | PSORAS1nucleotide-binding oligomerization domain containing 2-HPRD,BioGRID11087742 
Nod2 interaction with RICK enhances NF-kappaB activityBIND11087742 
PHB2BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22prohibitin 2Affinity Capture-MSBioGRID17353931 
RPL38-ribosomal protein L38Affinity Capture-MSBioGRID17353931 
RPS14EMTBribosomal protein S14Affinity Capture-MSBioGRID17353931 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD,BioGRID9642260 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1-HPRD,BioGRID9705938 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID9705938 
TRAF5MGC:39780 | RNF84TNF receptor-associated factor 5-HPRD,BioGRID9642260 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD,BioGRID9642260 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
TUBB2BDKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1tubulin, beta 2B-HPRD14743216 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
PID_NFKAPPAB_CANONICAL_PATHWAY 2320All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_DOWNSTREAM_TCR_SIGNALING 3732All SZGR genes in this pathway
REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES 128All SZGR genes in this pathway
REACTOME_P75NTR_SIGNALS_VIA_NFKB 1410All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 2317All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 169All SZGR genes in this pathway
REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION 1812All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_NOD1_2_SIGNALING_PATHWAY 3022All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 4633All SZGR genes in this pathway
NAKAMURA_CANCER_MICROENVIRONMENT_DN 4629All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON 13282All SZGR genes in this pathway
SANA_TNF_SIGNALING_UP 8356All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway


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