Gene Page: ACVR1

Summary
GeneID  90
Symbol  ACVR1
Synonyms  ACTRI|ACVR1A|ACVRLK2|ALK2|FOP|SKR1|TSRI
Description  activin A receptor, type I
See related  HGNC:171|MIM:102576|Ensembl:ENSG00000115170|HPRD:00021|
Locus tag  -
Gene type  protein-coding
Map location  2q23-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RAD54L20.940.93
CELSR30.930.92
KIAA15490.930.92
USP490.930.92
DCX0.930.90
IGF1R0.930.93
ZMIZ10.920.91
BEND30.920.91
C20orf1170.910.92
PLXNA20.910.89
Top 10 negatively co-expressed genes
C5orf53-0.61-0.76
HLA-F-0.59-0.74
AIFM3-0.59-0.74
SLC16A11-0.59-0.64
ALDOC-0.59-0.70
SERPINB6-0.58-0.70
LHPP-0.58-0.59
PTH1R-0.58-0.71
HEPN1-0.58-0.70
FBXO2-0.58-0.62
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004872receptor activityIEA-
GO:0005524ATP bindingIDA12065756 
GO:0016740transferase activityIEA-
GO:0016361activin receptor activity, type IIDA8242742 
GO:0042803protein homodimerization activityIDA18436533 
GO:0030145manganese ion bindingIEA-
GO:0048184follistatin bindingNAS12702211 
GO:0048185activin bindingIDA8242742 
GO:0046332SMAD bindingIDA12065756 
GO:0050431transforming growth factor beta bindingIDA8242742 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleIMP9884026 
GO:0001755neural crest cell migrationIEA-
GO:0001569patterning of blood vesselsIEA-
GO:0001701in utero embryonic developmentIEA-
GO:0001702gastrulation with mouth forming secondIEA-
GO:0001707mesoderm formationIEA-
GO:0002526acute inflammatory responseIEA-
GO:0006468protein amino acid phosphorylationIDA12065756 
GO:0007368determination of left/right symmetryIEA-
GO:0007281germ cell developmentIEA-
GO:0007179transforming growth factor beta receptor signaling pathwayIDA8242742 
GO:0009790embryonic developmentIEA-
GO:0007507heart developmentIEA-
GO:0007498mesoderm developmentIEA-
GO:0043066negative regulation of apoptosisIMP9884026 
GO:0060037pharyngeal system developmentIEA-
GO:0030501positive regulation of bone mineralizationIMP18436533 
GO:0030509BMP signaling pathwayIDA18436533 
GO:0051145smooth muscle cell differentiationIEA-
GO:0030278regulation of ossificationIMP16642017 
GO:0032926negative regulation of activin receptor signaling pathwayIMP9884026 
GO:0045941positive regulation of transcriptionIDA8242742 
GO:0045669positive regulation of osteoblast differentiationIMP18436533 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0045177apical part of cellIEA-
GO:0048179activin receptor complexIDA8242742 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR1BACTRIB | ACVRLK4 | ALK4 | SKR2activin A receptor, type IB-HPRD,BioGRID8612709 
BMP2BMP2Abone morphogenetic protein 2-HPRD8006002 
BMP7OP-1bone morphogenetic protein 7-HPRD,BioGRID8006002 
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)Affinity Capture-Western
Two-hybrid		BioGRID7791754 
ENGCD105 | END | FLJ41744 | HHT1 | ORW | ORW1endoglin-HPRD,BioGRID9872992 
FNTAFPTA | MGC99680 | PGGT1A | PTAR2farnesyltransferase, CAAX box, alpha-HPRD,BioGRID8599089 
GDF5BMP14 | CDMP1 | LAP4 | SYNS2growth differentiation factor 5-HPRD,BioGRID8702914 
IGSF1IGCD1 | IGDC1 | INHBP | KIAA0364 | MGC75490 | PGSF2immunoglobulin superfamily, member 1-HPRD11266516 
INHBAEDF | FRPinhibin, beta A-HPRD11266516 
INHBBMGC157939inhibin, beta B-HPRD11266516 
INHBCIHBCinhibin, beta C-HPRD12651901 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1-HPRD9748228 |10583507 
|10652350 
Affinity Capture-WesternBioGRID9748228 |10652350 
SMAD5DKFZp781C1895 | DKFZp781O1323 | Dwfc | JV5-1 | MADH5SMAD family member 5Affinity Capture-WesternBioGRID9748228 |10652350 
-HPRD9748228 |10583507 
|10652350 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_ALK2_PATHWAY 119All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP 7950All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
DORSEY_GAB2_TARGETS 3117All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_DN 1814All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP 6946All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP 10457All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
IKEDA_MIR1_TARGETS_UP 5339All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1075685741Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-1281911971Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/3014194261A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1373903961Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-140167173m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-148/152449455m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1824814881A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-271911981A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p5925991A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-314804861Ahsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-3298208261Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-3301171241A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3386167m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-3653023091A,m8hsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-381105210581Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-382630636m8hsa-miR-382brainGAAGUUGUUCGUGGUGGAUUCG
miR-384424430m8hsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-93.hd/291-3p/294/295/302/372/373/5206586641Ahsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
miR-964824881Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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