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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MAP3K14

Summary

GeneID

9020

Symbol

MAP3K14

Synonyms

FTDCR1B|HS|HSNIK|NIK

Description

mitogen-activated protein kinase kinase kinase 14

Locus tag

Gene type

protein-coding

Map location

17q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1134

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SLC2A6

0.89

CHAC1

0.86

0.89

SLC27A4

0.86

0.85

SEZ6L2

0.85

0.88

CHPF

0.85

0.87

PPP2R5B

0.84

0.85

LENG4

0.83

0.88

ATP13A2

0.83

0.82

ZDHHC14

0.83

0.85

SLC45A1

0.83

0.84

Top 10 negatively co-expressed genes

NSBP1

-0.48

-0.51

AF347015.21

-0.45

-0.33

RAB13

-0.45

-0.54

AF347015.18

-0.45

-0.36

AF347015.8

-0.43

-0.32

MT-ATP8

-0.43

-0.33

AP002478.3

-0.43

-0.42

AF347015.2

-0.42

-0.28

ANP32B

-0.41

-0.46

AF347015.31

-0.40

-0.31

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005515

protein binding

IPI

9520446 |10094049 |10733566
|11035039 |12874243
|16286467 |18022362

GO:0005524

ATP binding

IEA

GO:0004672

protein kinase activity

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0004709

MAP kinase kinase kinase activity

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATP5A1	ATP5A \| ATP5AL2 \| ATPM \| MOM2 \| OMR \| ORM \| hATP1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	-	HPRD	14743216
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Affinity Capture-Western	BioGRID	11002417
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	Affinity Capture-Western	BioGRID	11002417
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11002417
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	Affinity Capture-Western	BioGRID	11002417
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD,BioGRID	9244310
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	Ikk-alpha interacts with NIK. This interaction was modeled on a demonstrated interaction between human IKK-alpha and NIK from an unspecified species.	BIND	9346485
CSDA	CSDA1 \| DBPA \| ZONAB	cold shock domain protein A	-	HPRD	14743216
DHX9	DDX9 \| LKP \| NDHII \| RHA	DEAH (Asp-Glu-Ala-His) box polypeptide 9	-	HPRD	14743216
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	11116146
EXOSC10	PM-Scl \| PM/Scl-100 \| PMSCL \| PMSCL2 \| RRP6 \| Rrp6p \| p2 \| p3 \| p4	exosome component 10	-	HPRD	14743216
GLUD1	GDH \| GDH1 \| GLUD \| MGC132003	glutamate dehydrogenase 1	-	HPRD	14743216
GRWD1	GRWD \| KIAA1942 \| RRB1 \| WDR28	glutamate-rich WD repeat containing 1	-	HPRD	14743216
HNRNPA1	HNRPA1 \| MGC102835	heterogeneous nuclear ribonucleoprotein A1	-	HPRD	14743216
HNRNPM	DKFZp547H118 \| HNRNPM4 \| HNRPM \| HNRPM4 \| HTGR1 \| NAGR1	heterogeneous nuclear ribonucleoprotein M	-	HPRD	14743216
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD	14743216
IKBKAP	DKFZp781H1425 \| DYS \| ELP1 \| FD \| FLJ12497 \| IKAP \| IKI3 \| TOT1	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	-	HPRD,BioGRID	9751059
IKBKAP			IKAP interacts with NIK.	BIND	9751059
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	IKK-beta interacts with NIK. This interaction was modeled on a demonstrated interaction between human IKK-beta and NIK from an unspecified species.	BIND	9346485
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB		-	HPRD,BioGRID	9346485
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	-	HPRD,BioGRID	9927690
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	10887201
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD,BioGRID	10094049
MAP3K8	COT \| EST \| ESTF \| FLJ10486 \| TPL2 \| Tpl-2 \| c-COT	mitogen-activated protein kinase kinase kinase 8	-	HPRD,BioGRID	10072079
NFKB2	LYT-10 \| LYT10	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	-	HPRD,BioGRID	11239468
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Reconstituted Complex	BioGRID	9751059
NPM1	B23 \| MGC104254 \| NPM	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	-	HPRD	14743216
PELI3	MGC35521	pellino homolog 3 (Drosophila)	-	HPRD	12874243
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD,BioGRID	11116146
RPL10A	Csa-19 \| NEDD6	ribosomal protein L10a	-	HPRD	14743216
RPL18	-	ribosomal protein L18	-	HPRD	14743216
RPL24	-	ribosomal protein L24	-	HPRD	14743216
RPL3	MGC104284 \| TARBP-B	ribosomal protein L3	-	HPRD	14743216
RPL32	PP9932	ribosomal protein L32	-	HPRD	14743216
RPL35	-	ribosomal protein L35	-	HPRD	14743216
RPL8	-	ribosomal protein L8	-	HPRD	14743216
RPS3	FLJ26283 \| FLJ27450 \| MGC87870	ribosomal protein S3	-	HPRD	14743216
RRP12	DKFZp762P1116 \| FLJ20231 \| KIAA0690	ribosomal RNA processing 12 homolog (S. cerevisiae)	-	HPRD	14743216
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	-	HPRD	14743216
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	-	HPRD,BioGRID	11278268
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	NIK interacts with TRAF1. This interaction was modeled on a demonstrated interaction between human NIK and TRAF1 from an unspecified species.	BIND	9275204
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD,BioGRID	9020361 \|11278268
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	NIK interacts with TRAF2. This interaction was modeled on a demonstrated interaction between human NIK and TRAF2 from an unspecified species.	BIND	9275204
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	-	HPRD,BioGRID	11278268
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	NIK interacts with TRAF3. This interaction was modeled on a demonstrated interaction between human NIK and TRAF3 from an unspecified species.	BIND	9275204
TRAF5	MGC:39780 \| RNF84	TNF receptor-associated factor 5	NIK interacts with TRAF5. This interaction was modeled on a demonstrated interaction between human NIK and TRAF5 from an unspecified species.	BIND	9275204
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	11278268
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	NIK interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human NIK and TRAF6 from an unspecified species.	BIND	9275204
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	14743216
TUBB2B	DKFZp566F223 \| FLJ98847 \| MGC8685 \| TUBB-PARALOG \| bA506K6.1	tubulin, beta 2B	-	HPRD	14743216

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_APOPTOSIS	88	62	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION	48	36	All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	68	44	All SZGR genes in this pathway
BIOCARTA_CD40_PATHWAY	15	13	All SZGR genes in this pathway
BIOCARTA_RNA_PATHWAY	10	9	All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY	58	43	All SZGR genes in this pathway
BIOCARTA_DEATH_PATHWAY	33	24	All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY	46	38	All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY	87	68	All SZGR genes in this pathway
BIOCARTA_NTHI_PATHWAY	24	20	All SZGR genes in this pathway
BIOCARTA_NFKB_PATHWAY	23	19	All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY	33	29	All SZGR genes in this pathway
BIOCARTA_TALL1_PATHWAY	15	15	All SZGR genes in this pathway
BIOCARTA_STRESS_PATHWAY	25	18	All SZGR genes in this pathway
BIOCARTA_TNFR2_PATHWAY	18	15	All SZGR genes in this pathway
BIOCARTA_TOLL_PATHWAY	37	31	All SZGR genes in this pathway
PID_TCR_PATHWAY	66	51	All SZGR genes in this pathway
PID_CD40_PATHWAY	31	26	All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY	31	29	All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY	53	42	All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY	35	26	All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION	32	26	All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	63	48	All SZGR genes in this pathway
REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING	22	18	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP	183	119	All SZGR genes in this pathway
HOOI_ST7_TARGETS_UP	94	57	All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP	176	123	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN	64	39	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN	75	50	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN	378	231	All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP	239	157	All SZGR genes in this pathway
PEREZ_TP53_TARGETS	1174	695	All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS	58	45	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP	1037	673	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN	411	249	All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA	69	47	All SZGR genes in this pathway
AMIT_EGF_RESPONSE_60_MCF10A	39	24	All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_120_MCF10A	65	44	All SZGR genes in this pathway
STANELLE_E2F1_TARGETS	29	20	All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_UP	71	49	All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_DN	21	13	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_24HR	20	13	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN	120	81	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP	439	257	All SZGR genes in this pathway
FIRESTEIN_CTNNB1_PATHWAY_AND_PROLIFERATION	9	5	All SZGR genes in this pathway
FIRESTEIN_CTNNB1_PATHWAY	33	23	All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION	175	125	All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_B	53	36	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP	338	225	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN	235	144	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN	245	150	All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN	267	160	All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN	210	141	All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_1HR_UP	17	10	All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN	505	328	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_1HR_UP	34	26	All SZGR genes in this pathway
KRIEG_HYPOXIA_VIA_KDM3A	53	34	All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF	516	308	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY	1725	838	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	1013	1019	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-155	1247	1254	1A,m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d	1034	1040	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-19	1012	1018	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1012	1018	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-27	1260	1266	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1260	1266	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-93.hd/291-3p/294/295/302/372/373/520	1033	1039	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.