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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: HGS

Summary

GeneID

9146

Symbol

HGS

Synonyms

HRS|ZFYVE8

Description

hepatocyte growth factor-regulated tyrosine kinase substrate

Locus tag

Gene type

protein-coding

Map location

17q25

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0198

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

BYSL

0.92

PSMD3

0.92

DGCR14

0.92

0.91

USF1

0.92

0.94

HINFP

0.92

KAT5

0.92

0.93

DAXX

0.92

0.93

PRPF31

0.91

0.90

PUF60

0.91

DHPS

0.91

0.93

Top 10 negatively co-expressed genes

AF347015.27

-0.83

-0.89

AF347015.31

-0.83

-0.87

MT-CO2

-0.83

-0.86

AF347015.8

-0.82

-0.88

MT-CYB

-0.82

-0.87

AF347015.33

-0.81

-0.85

AF347015.15

-0.80

-0.86

AF347015.2

-0.78

-0.86

AF347015.21

-0.77

-0.87

AF347015.26

-0.76

-0.86

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008270

zinc ion binding

IEA

GO:0019904

protein domain specific binding

IPI

11984006

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007165

signal transduction

TAS

9407053

GO:0008285

negative regulation of cell proliferation

TAS

9407053

GO:0006886

intracellular protein transport

IEA

GO:0016197

endosome transport

NAS

10861283

GO:0042176

regulation of protein catabolic process

TAS

15611048

GO:0046426

negative regulation of JAK-STAT cascade

IDA

12444102

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

10567358 |12218189 |15962011

GO:0005737

cytoplasm

IEA

GO:0016020

membrane

IEA

GO:0031901

early endosome membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BEGAIN	KIAA1446	brain-enriched guanylate kinase-associated homolog (rat)	Two-hybrid	BioGRID	16189514
C1orf190	FLJ25163	chromosome 1 open reading frame 190	Two-hybrid	BioGRID	16189514
CCDC33	FLJ23168 \| FLJ32855 \| MGC34145	coiled-coil domain containing 33	Two-hybrid	BioGRID	16189514
CLTC	CHC \| CHC17 \| CLH-17 \| CLTCL2 \| Hc \| KIAA0034	clathrin, heavy chain (Hc)	-	HPRD,BioGRID	11532964
DAZAP2	KIAA0058 \| MGC14319 \| MGC766 \| PRTB	DAZ associated protein 2	Two-hybrid	BioGRID	16189514
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD,BioGRID	12151521
EHMT2	BAT8 \| C6orf30 \| DKFZp686H08213 \| FLJ35547 \| G9A \| KMT1C \| NG36 \| NG36/G9a	euchromatic histone-lysine N-methyltransferase 2	Two-hybrid	BioGRID	16189514
EPS15	AF-1P \| AF1P \| MLLT5	epidermal growth factor receptor pathway substrate 15	-	HPRD,BioGRID	12551915
EXOC7	2-5-3p \| DKFZp686J04253 \| EX070 \| EXO70 \| EXOC1 \| Exo70p \| FLJ40965 \| FLJ46415 \| YJL085W	exocyst complex component 7	Two-hybrid	BioGRID	16189514
EXOC8	EXO84 \| Exo84p \| SEC84	exocyst complex component 8	Two-hybrid	BioGRID	16189514
GKAP1	FKSG21 \| FLJ25469 \| GKAP42	G kinase anchoring protein 1	Two-hybrid	BioGRID	16189514
HAP1	HAP2 \| HIP5 \| HLP \| hHLP1	huntingtin-associated protein 1	-	HPRD,BioGRID	12021262
KRT18	CYK18 \| K18	keratin 18	Two-hybrid	BioGRID	16189514
KRT19	CK19 \| K19 \| K1CS \| MGC15366	keratin 19	Two-hybrid	BioGRID	16189514
LDOC1	BCUR1 \| Mar7 \| Mart7	leucine zipper, down-regulated in cancer 1	Two-hybrid	BioGRID	16189514
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD,BioGRID	11984006
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD,BioGRID	11397816
MED7	CRSP33 \| CRSP9 \| MGC12284	mediator complex subunit 7	Two-hybrid	BioGRID	16189514
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	-	HPRD	8380735
MIF4GD	AD023 \| MGC45027 \| MIFD \| SLIP1	MIF4G domain containing	Two-hybrid	BioGRID	16189514
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD,BioGRID	12230472
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	-	HPRD,BioGRID	10861283 \|11285248
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	merlin interacts with HRS.	BIND	12444101
NMI	-	N-myc (and STAT) interactor	Two-hybrid	BioGRID	16189514
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD,BioGRID	11397816
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	10970851
SNAP25	FLJ23079 \| RIC-4 \| RIC4 \| SEC9 \| SNAP \| SNAP-25 \| bA416N4.2 \| dJ1068F16.2	synaptosomal-associated protein, 25kDa	-	HPRD	10825299 \|11493665\|11493665
SNAP25		synaptosomal-associated protein, 25kDa	-	HPRD	11493665
SNX1	HsT17379 \| MGC8664 \| SNX1A \| Vps5	sorting nexin 1	-	HPRD,BioGRID	11110793
STAM	DKFZp686J2352 \| STAM1	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	-	HPRD,BioGRID	9407053
STAM2	DKFZp564C047 \| Hbp \| STAM2A \| STAM2B	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Affinity Capture-Western Co-fractionation Two-hybrid	BioGRID	12551915 \|16189514
TADA2L	ADA2 \| ADA2A \| FLJ12705 \| KL04P \| hADA2	transcriptional adaptor 2 (ADA2 homolog, yeast)-like	Two-hybrid	BioGRID	16189514
TSG101	TSG10 \| VPS23	tumor susceptibility gene 101	TSG101 interacts with HGS (Hrs).	BIND	14519844
			Affinity Capture-Western Two-hybrid	BioGRID	12802020 \|16189514
			HRS interacts with TSG101.	BIND	12802020
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Two-hybrid	BioGRID	16189514
UBQLN1	DA41 \| DSK2 \| FLJ90054 \| PLIC-1 \| XDRP1	ubiquilin 1	Two-hybrid	BioGRID	16189514
USHBP1	AIEBP \| FLJ38709 \| FLJ90681 \| MCC2	Usher syndrome 1C binding protein 1	Two-hybrid	BioGRID	16189514
VPS37A	FLJ32642 \| FLJ42616 \| HCRP1 \| PQBP2	vacuolar protein sorting 37 homolog A (S. cerevisiae)	-	HPRD	15240819 \|15509564
VPS37C	FLJ20847	vacuolar protein sorting 37 homolog C (S. cerevisiae)	-	HPRD,BioGRID	15509564

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ENDOCYTOSIS	183	132	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_CXCR4_PATHWAY	102	78	All SZGR genes in this pathway
PID_AJDISS_2PATHWAY	48	38	All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY	41	35	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING	129	74	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
REACTOME_EGFR_DOWNREGULATION	25	14	All SZGR genes in this pathway
REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT	27	15	All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP	276	187	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP	293	179	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC	108	74	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP	769	437	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
TAGHAVI_NEOPLASTIC_TRANSFORMATION	12	10	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON	335	181	All SZGR genes in this pathway
GRADE_COLON_CANCER_UP	871	505	All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION	175	125	All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP	188	121	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP	140	94	All SZGR genes in this pathway