Gene Page: CD247

Summary
GeneID  919
Symbol  CD247
Synonyms  CD3-ZETA|CD3H|CD3Q|CD3Z|T3Z|TCRZ
Description  CD247 molecule
See related  HGNC:1677|MIM:186780|Ensembl:ENSG00000198821|HPRD:01729|
Locus tag  -
Gene type  protein-coding
Map location  1q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SECTM10.640.27
C19orf350.630.43
KISS1R0.620.21
PTGER10.570.42
SMOC20.560.54
AC011500.20.540.31
C1orf1330.540.39
P2RY10.540.27
RXRG0.520.33
FAM40B0.510.36
Top 10 negatively co-expressed genes
C18orf8-0.44-0.58
GTDC1-0.43-0.47
GARNL3-0.42-0.52
CABYR-0.41-0.58
ZNF30-0.40-0.56
CBARA1-0.40-0.53
SFXN3-0.40-0.51
DYNC1I1-0.39-0.48
RNF8-0.39-0.51
RAD51C-0.39-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0042803protein homodimerization activityNAS12110186 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007166cell surface receptor linked signal transductionIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexIDASynap (GO term level: 8)8176201 
GO:0005737cytoplasmIDA11390434 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP11048639 |11827988 |15489916 
|17652306 
GO:0005886plasma membraneIDA1390434 |11390434 
GO:0042105alpha-beta T cell receptor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATXN2ATX2 | FLJ46772 | SCA2 | TNRC13ataxin 2Affinity Capture-WesternBioGRID9575182 
CD2SRBC | T11CD2 molecule-HPRD8977276 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD2845582 
CD28MGC138290 | Tp44CD28 molecule-HPRD8760790 
CD3DCD3-DELTA | T3DCD3d molecule, delta (CD3-TCR complex)-HPRD9485181 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)-HPRD9485181 
CD5LEU1 | T1CD5 molecule-HPRD1385158 
CSKMGC117393c-src tyrosine kinase-HPRD9172452 
DOCK2FLJ46592 | KIAA0209dedicator of cytokinesis 2-HPRD,BioGRID12176041 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID11572860 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD,BioGRID11349123 
LY6ERIG-E | RIGE | SCA-2 | SCA2 | TSA-1lymphocyte antigen 6 complex, locus E-HPRD9575182 
NCR1CD335 | LY94 | NK-p46 | NKP46natural cytotoxicity triggering receptor 1-HPRD,BioGRID9625766 
NCR31C7 | CD337 | LY117 | MALS | NKp30natural cytotoxicity triggering receptor 3-HPRD12731048 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID7526385 
SH2B3CELIAC13 | LNKSH2B adaptor protein 3-HPRD10799879 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD8656061 
SLASLA1 | SLAPSrc-like-adaptor-HPRD,BioGRID10449770 
SLA2C20orf156 | FLJ21992 | MGC49845 | SLAP-2 | SLAP2Src-like-adaptor 2-HPRD,BioGRID11891219 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID9880255 
STAT5BSTAT5signal transducer and activator of transcription 5B-HPRD,BioGRID9880255 
TFRCCD71 | TFR | TFR1 | TRFRtransferrin receptor (p90, CD71)-HPRD9448136 
TIRAPFLJ42305 | Mal | wyatttoll-interleukin 1 receptor (TIR) domain containing adaptor protein-HPRD11572860 
TRA@FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRAT cell receptor alpha locus-HPRD2138083 
TRAT1HSPC062 | TCRIM | TRIMT cell receptor associated transmembrane adaptor 1-HPRD9687533 |11390434 
-HPRD,BioGRID11390434 
UNC119HRG4unc-119 homolog (C. elegans)-HPRD,BioGRID14757743 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD8366117 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_CTL_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_TCAPOPTOSIS_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_IL17_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_IL12_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_TCRA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_NO2IL12_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_TOB1_PATHWAY 2114All SZGR genes in this pathway
BIOCARTA_STATHMIN_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
BIOCARTA_TCYTOTOXIC_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_THELPER_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_CTLA4_PATHWAY 2118All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_DOWNSTREAM_TCR_SIGNALING 3732All SZGR genes in this pathway
REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS 1615All SZGR genes in this pathway
REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE 1414All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_PD1_SIGNALING 1814All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 2819All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_DN 1816All SZGR genes in this pathway
SCHLINGEMANN_SKIN_CARCINOGENESIS_TPA_DN 2915All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
FINAK_BREAST_CANCER_SDPP_SIGNATURE 2611All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-214410416m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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