Gene Page: ACVR2A

Summary
GeneID  92
Symbol  ACVR2A
Synonyms  ACTRII|ACVR2
Description  activin A receptor, type IIA
See related  HGNC:173|MIM:102581|Ensembl:ENSG00000121989|HPRD:00025|
Locus tag  -
Gene type  protein-coding
Map location  2q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ABHD14A0.960.95
TEX2640.870.83
ISOC20.860.88
CYC10.840.81
FASTK0.840.83
MARCH20.840.81
MFSD30.830.86
C11orf590.830.86
SLC25A110.830.78
GPX40.830.83
Top 10 negatively co-expressed genes
EIF5B-0.60-0.70
RBM25-0.53-0.55
SFRS12-0.53-0.53
ZNF326-0.52-0.50
AC005921.3-0.49-0.69
THOC2-0.48-0.47
PPIG-0.47-0.45
PRPF38B-0.47-0.47
SFRS18-0.46-0.58
ESF1-0.45-0.41
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0019838growth factor bindingIEA-
GO:0017002activin receptor activityIDA12665502 
GO:0015026coreceptor activityIDA10746731 
GO:0030145manganese ion bindingIEA-
GO:0048185activin bindingIPI9032295 
GO:0048186inhibin beta-A bindingIDA7890768 
GO:0043621protein self-associationIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001702gastrulation with mouth forming secondIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007368determination of left/right symmetryIEA-
GO:0007283spermatogenesisIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0007498mesoderm developmentIEA-
GO:0050999regulation of nitric-oxide synthase activityIEA-
GO:0042713sperm ejaculationIEA-
GO:0030501positive regulation of bone mineralizationIMP18436533 
GO:0030509BMP signaling pathwayEXP15621726 
GO:0030509BMP signaling pathwayIDA18436533 
GO:0043084penile erectionIEA-
GO:0032927positive regulation of activin receptor signaling pathwayIDA12665502 
GO:0045648positive regulation of erythrocyte differentiationIDA9032295 
GO:0045669positive regulation of osteoblast differentiationIMP18436533 
GO:0048706embryonic skeletal system developmentIEA-
GO:0060011Sertoli cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIDA14738881 
GO:0005886plasma membraneEXP17356069 
GO:0005887integral to plasma membraneTAS1314589 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR1BACTRIB | ACVRLK4 | ALK4 | SKR2activin A receptor, type IB-HPRD,BioGRID8612709 
BMP6VGR | VGR1bone morphogenetic protein 6-HPRD,BioGRID10504300 
BMP7OP-1bone morphogenetic protein 7-HPRD,BioGRID9748228 
ENGCD105 | END | FLJ41744 | HHT1 | ORW | ORW1endoglin-HPRD,BioGRID9872992 
GDF5BMP14 | CDMP1 | LAP4 | SYNS2growth differentiation factor 5-HPRD,BioGRID8702914 
GDF9-growth differentiation factor 9-HPRD12135884 
IGSF1IGCD1 | IGDC1 | INHBP | KIAA0364 | MGC75490 | PGSF2immunoglobulin superfamily, member 1-HPRD11266516 
INHA-inhibin, alphaAffinity Capture-WesternBioGRID10746731 
INHBAEDF | FRPinhibin, beta AAffinity Capture-WesternBioGRID9202237 |10746731 
-HPRD11266516 
INHBBMGC157939inhibin, beta BAffinity Capture-WesternBioGRID9202237 
-HPRD11266516 
INHBCIHBCinhibin, beta C-HPRD12651901 
MAGI2ACVRIP1 | AIP1 | ARIP1 | MAGI-2 | SSCAMmembrane associated guanylate kinase, WW and PDZ domain containing 2-HPRD10681527 
SYNJ2BPARIP2 | FLJ11271 | FLJ41973 | OMP25synaptojanin 2 binding protein-HPRD,BioGRID11882656 |15451561 
TGFBR3BGCAN | betaglycantransforming growth factor, beta receptor III-HPRD10746731 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NODAL 1811All SZGR genes in this pathway
REACTOME_SIGNALING_BY_BMP 2315All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN 8463All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70 6733All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_UP 8455All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
MATZUK_CENTRAL_FOR_FEMALE_FERTILITY 2925All SZGR genes in this pathway
MATZUK_MALE_REPRODUCTION_SERTOLI 2823All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_UP 6644All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/985895951Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1/206351235181Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124.114201426m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506142014261Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-125/351127912851Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-128676682m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/301285328601A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-138326632721Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-141/200a26892695m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-3p172517321A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1459709761Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/49747531Ahsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1501531591Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-153131213181Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-155559565m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-181489495m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-18311701176m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-1852652711Ahsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-188128112871Ahsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-192/215179718041A,m8hsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-193159115971Ahsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-19623412347m8hsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-1999689751A,m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429159316001A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-203.13984041Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2152581Ahsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-21732843290m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-2233123191A,m8hsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-27168216891A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-2925442550m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-5p240124071Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-362275281m8hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-369-3p15951601m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3746126181Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-378109511011Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-380-5p326332691Ahsa-miR-380-5pUGGUUGACCAUAGAACAUGCGC
hsa-miR-563AGGUUGACAUACGUUUCCC
miR-38127292735m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-409-5p133013371A,m8hsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
miR-448131113181A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p348634921Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-495330733131Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-50347531Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-54323282334m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-96715721m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.