Gene Page: CD4

Summary
GeneID  920
Symbol  CD4
Synonyms  CD4mut
Description  CD4 molecule
See related  HGNC:1678|MIM:186940|Ensembl:ENSG00000010610|HPRD:01740|
Locus tag  -
Gene type  protein-coding
Map location  12pter-p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RNF440.680.71
SCMH10.670.70
STK11IP0.660.68
NPHP40.650.67
MPPE10.650.69
TAOK20.650.66
ULK10.650.68
CCRK0.650.67
ZMIZ20.650.70
TAF60.640.68
Top 10 negatively co-expressed genes
AF347015.31-0.53-0.55
AF347015.21-0.52-0.56
MT-CO2-0.51-0.53
AL139819.3-0.50-0.55
AF347015.2-0.49-0.50
MT-CYB-0.48-0.51
AF347015.8-0.48-0.51
GNG11-0.47-0.55
HIGD1B-0.47-0.51
AF347015.26-0.46-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityTAS10358157 
GO:0001948glycoprotein bindingIPI10922058 
GO:0005201extracellular matrix structural constituentNAS12444132 
GO:0008270zinc ion bindingIDA9668045 
GO:0042289MHC class II protein bindingNAS8512039 
GO:0015026coreceptor activityNAS8512039 
GO:0042803protein homodimerization activityIDA12444132 
GO:0019901protein kinase bindingIPI7486703 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000747conjugation with cellular fusionIDA9166430 
GO:0001816cytokine productionIEA-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayNAS8512039 
GO:0007155cell adhesionIEA-
GO:0006955immune responseNAS8512039 
GO:0019059initiation of viral infectionEXP12091904 
GO:0050870positive regulation of T cell activationIEA-
GO:0045860positive regulation of protein kinase activityIDA2118992 
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA-
GO:0050850positive regulation of calcium-mediated signalingIEA-
GO:0045086positive regulation of interleukin-2 biosynthetic processNAS1901411 
GO:0045058T cell selectionIDA9551897 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexNASSynap (GO term level: 8)8512039 
GO:0005789endoplasmic reticulum membraneEXP9660940 
GO:0005769early endosomeEXP2014052 |15202998 
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneEXP2014052 |11048639 |11827988 
|15202998 |15489916 
|17652306 
GO:0005886plasma membraneIDA8124721 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containing-HPRD,BioGRID9660940 
CCR5CC-CKR-5 | CCCKR5 | CD195 | CKR-5 | CKR5 | CMKBR5chemokine (C-C motif) receptor 5-HPRD,BioGRID10816381 
CD2SRBC | T11CD2 molecule-HPRD7539755 
CD28MGC138290 | Tp44CD28 molecule-HPRD7539755 
CD38T10CD38 molecule-HPRD7539755 
CD4CD4mutCD4 moleculeCD4 forms homodimers.BIND12444132 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD7539755 
CD5LEU1 | T1CD5 molecule-HPRD7539755 
CD53MOX44 | TSPAN25CD53 molecule-HPRD7539755 
CD81S5.7 | TAPA1 | TSPAN28CD81 moleculeAffinity Capture-WesternBioGRID7636191 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD,BioGRID7636191 
CTSDCLN10 | CPSD | MGC2311cathepsin D-HPRD11581410 
CXCL12PBSF | SCYB12 | SDF-1a | SDF-1b | SDF1 | SDF1A | SDF1B | TLSF-a | TLSF-b | TPAR1chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)-HPRD10600606 
CXCR4CD184 | D2S201E | FB22 | HM89 | HSY3RR | LAP3 | LCR1 | LESTR | NPY3R | NPYR | NPYRL | NPYY3R | WHIMchemokine (C-X-C motif) receptor 4Affinity Capture-WesternBioGRID10816381 
FCGR3ACD16 | CD16A | FCG3 | FCGR3 | FCGRIII | FCR-10 | FCRIII | FCRIIIA | IGFR3Fc fragment of IgG, low affinity IIIa, receptor (CD16a)-HPRD11756173 
HLA-DPA1HLA-DP1A | HLADP | HLASBmajor histocompatibility complex, class II, DP alpha 1-HPRD12899833 
HLA-DQA2HLA-DXAmajor histocompatibility complex, class II, DQ alpha 2-HPRD11535811 
IL16FLJ16806 | FLJ42735 | FLJ44234 | HsT19289 | IL-16 | LCF | prIL-16interleukin 16 (lymphocyte chemoattractant factor)-HPRD,BioGRID1851800|7910967 
IL2RACD25 | IDDM10 | IL2R | TCGFRinterleukin 2 receptor, alpha-HPRD7539755 
KCNAB2AKR6A5 | HKvbeta2 | HKvbeta2.1 | HKvbeta2.2 | KCNA2B | KV-BETA-2 | MGC117289potassium voltage-gated channel, shaker-related subfamily, beta member 2Affinity Capture-WesternBioGRID12893943 
LATLAT1 | pp36linker for activation of T cells-HPRD10562325 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID11854499 
LGALS1DKFZp686E23103 | GAL1 | GBPlectin, galactoside-binding, soluble, 1in vitroBioGRID10490978 
MARCH4MARCH-IV | MGC104908 | RNF174membrane-associated ring finger (C3HC4) 4-HPRD14722266 
PI4KAFLJ16556 | PI4K-ALPHA | PIK4CA | pi4K230phosphatidylinositol 4-kinase, catalytic, alpha-HPRD8246987 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD8246987 
PIPGCDFP-15 | GCDFP15 | GPIP4prolactin-induced protein-HPRD,BioGRID10820003 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD10384144 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID1834739 
SELLCD62L | LAM-1 | LAM1 | LECAM1 | LNHR | LSEL | LYAM1 | Leu-8 | Lyam-1 | PLNHR | TQ1 | hLHRcselectin L-HPRD7539755 
SPG21ACP33 | BM-019 | GL010 | MASPARDIN | MASTspastic paraplegia 21 (autosomal recessive, Mast syndrome)-HPRD,BioGRID11113139 
TNFRSF10AAPO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1tumor necrosis factor receptor superfamily, member 10a-HPRD7650480 
UNC119HRG4unc-119 homolog (C. elegans)-HPRD,BioGRID14757743 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_PRIMARY_IMMUNODEFICIENCY 3528All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_ASBCELL_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_TCAPOPTOSIS_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_IL17_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_IL5_PATHWAY 109All SZGR genes in this pathway
BIOCARTA_TCRA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_NO2IL12_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_STEM_PATHWAY 1513All SZGR genes in this pathway
BIOCARTA_NKT_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_THELPER_PATHWAY 1411All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_IL23_PATHWAY 3730All SZGR genes in this pathway
PID_ARF_3PATHWAY 1913All SZGR genes in this pathway
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS 2112All SZGR genes in this pathway
REACTOME_DEFENSINS 5112All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_DOWNSTREAM_TCR_SIGNALING 3732All SZGR genes in this pathway
REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS 1615All SZGR genes in this pathway
REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE 1414All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_PD1_SIGNALING 1814All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 218All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 2819All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
SHANK_TAL1_TARGETS_DN 106All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA 7038All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_UP 2923All SZGR genes in this pathway
NIELSEN_GIST_AND_SYNOVIAL_SARCOMA_DN 2015All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
LEE_LIVER_CANCER 4929All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
WILENSKY_RESPONSE_TO_DARAPLADIB 2920All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
FONTAINE_THYROID_TUMOR_UNCERTAIN_MALIGNANCY_UP 3623All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
MOOTHA_GLUCONEOGENESIS 3223All SZGR genes in this pathway
MOOTHA_GLYCOLYSIS 2113All SZGR genes in this pathway
NIELSEN_SYNOVIAL_SARCOMA_DN 2013All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_UP 6144All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-18174811A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-221/22277841A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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