Gene Page: CD8A

Summary
GeneID  925
Symbol  CD8A
Synonyms  CD8|Leu2|MAL|p32
Description  CD8a molecule
See related  HGNC:1706|MIM:186910|Ensembl:ENSG00000153563|HPRD:01737|
Locus tag  -
Gene type  protein-coding
Map location  2p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MMP250.610.56
KCTD110.570.56
DPEP10.570.54
NT5DC20.570.54
AC006273.10.560.51
ISYNA10.560.55
COMTD10.560.47
PPDPF0.560.46
PVRL20.560.51
RAC30.560.46
Top 10 negatively co-expressed genes
ALDOC-0.43-0.45
RGN-0.42-0.47
FBXO2-0.42-0.44
OMG-0.41-0.48
C5orf53-0.41-0.48
CSRP1-0.41-0.45
CCNI2-0.40-0.44
SPARCL1-0.40-0.44
CA2-0.39-0.47
ANXA11-0.39-0.44
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI2470098 |2493728 
GO:0042288MHC class I protein bindingNAS11131152 
GO:0015026coreceptor activityNAS11131152 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002456T cell mediated immunityIEA-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayNAS9830036 
GO:0007166cell surface receptor linked signal transductionIEA-
GO:0019882antigen processing and presentationNAS2496167 
GO:0006955immune responseNAS11131152 
GO:0042110T cell activationNAS9830036 
GO:0050850positive regulation of calcium-mediated signalingIEA-
GO:0045065cytotoxic T cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexNASSynap (GO term level: 8)11131152 
GO:0005576extracellular regionIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneNAS2496167 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD3DCD3-DELTA | T3DCD3d molecule, delta (CD3-TCR complex)-HPRD,BioGRID12215456 
CD5916.3A5 | 1F5 | EJ16 | EJ30 | EL32 | FLJ38134 | FLJ92039 | G344 | HRF-20 | HRF20 | MAC-IP | MACIF | MEM43 | MGC2354 | MIC11 | MIN1 | MIN2 | MIN3 | MIRL | MSK21 | p18-20CD59 molecule, complement regulatory proteinReconstituted ComplexBioGRID1377690 
CD8ACD8 | Leu2 | MAL | p32CD8a moleculeCo-crystal Structure
Co-localization		BioGRID8127870 |9550407 
-HPRD8127870 |10809759 
CD8BCD8B1 | LYT3 | Leu2 | Ly3 | MGC119115CD8b molecule-HPRD,BioGRID3145195 |9550407 
|10623829|10809759 
HLA-AHLAAmajor histocompatibility complex, class I, A-HPRD,BioGRID9177355 |10809759|10809759 
HLA-BAS | HLA-B-7301 | HLA-B73 | HLAB | HLAC | SPDA1major histocompatibility complex, class I, B-HPRD,BioGRID9331948 |10809759|10809759 
HLA-CD6S204 | FLJ27082 | HLA-Cw | HLA-Cw12 | HLA-JY3 | HLC-C | PSORS1major histocompatibility complex, class I, C-HPRD,BioGRID10809759 
HLA-EDKFZp686P19218 | EA1.2 | EA2.1 | HLA-6.2 | MHC | QA1major histocompatibility complex, class I, E-HPRD10809759 
HLA-GMHC-Gmajor histocompatibility complex, class I, G-HPRD1908512 |10843658|10809759 
in vivo
Reconstituted Complex		BioGRID1908512 |10809759 
|10843658 
LATLAT1 | pp36linker for activation of T cells-HPRD10562325 
LGALS1DKFZp686E23103 | GAL1 | GBPlectin, galactoside-binding, soluble, 1-HPRD,BioGRID10490978 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID1834739 
SFRS12DKFZp564B176 | MGC133045 | SRrp508 | SRrp86splicing factor, arginine/serine-rich 12-HPRD14559993 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_PRIMARY_IMMUNODEFICIENCY 3528All SZGR genes in this pathway
BIOCARTA_IL17_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_STEM_PATHWAY 1513All SZGR genes in this pathway
BIOCARTA_TCYTOTOXIC_PATHWAY 1411All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP 177110All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_UP 11668All SZGR genes in this pathway
TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA 10358All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_1 4423All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5 9459All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_1_UP 3525All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
LEE_DOUBLE_POLAR_THYMOCYTE 2717All SZGR genes in this pathway
FINAK_BREAST_CANCER_SDPP_SIGNATURE 2611All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
CHIARETTI_T_ALL_RELAPSE_PROGNOSIS 1915All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1861511571Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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