Gene Page: CNOT8

Summary
GeneID  9337
Symbol  CNOT8
Synonyms  CAF1|CALIF|POP2|hCAF1
Description  CCR4-NOT transcription complex, subunit 8
See related  HGNC:9207|MIM:603731|Ensembl:ENSG00000155508|HPRD:07225|
Locus tag  -
Gene type  protein-coding
Map location  5q31-q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BUB30.920.90
H2AFY0.920.89
CSTF20.920.91
POLDIP30.920.91
ALDH18A10.910.90
USP390.910.89
SFRS10.910.89
TRA2B0.910.88
RFWD30.900.90
TH1L0.900.86
Top 10 negatively co-expressed genes
AF347015.27-0.70-0.84
MT-CO2-0.69-0.84
AF347015.33-0.69-0.82
AF347015.31-0.68-0.82
AF347015.8-0.67-0.83
FXYD1-0.67-0.80
MT-CYB-0.66-0.80
C5orf53-0.66-0.71
S100B-0.64-0.75
AF347015.21-0.64-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingIEA-
GO:0003700transcription factor activityNAS10036195 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentNAS10036195 
GO:0006350transcriptionIEA-
GO:0008285negative regulation of cell proliferationTAS9820826 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIDA11256614 
GO:0005634nucleusNAS10036195 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BTG1-B-cell translocation gene 1, anti-proliferative-HPRD,BioGRID11136725 
BTG2MGC126063 | MGC126064 | PC3 | TIS21BTG family, member 2-HPRD,BioGRID11136725 
CNOT1AD-005 | CDC39 | DKFZp686E0722 | DKFZp686O168 | FLJ36492 | FLJ90644 | KIAA1007 | NOT1 | NOT1HCCR4-NOT transcription complex, subunit 1-HPRD,BioGRID10637334 
CNOT10DKFZp434K115 | FLJ12890 | FLJ13165CCR4-NOT transcription complex, subunit 10Affinity Capture-MSBioGRID17353931 
CNOT3KIAA0691 | LENG2 | NOT3 | NOT3HCCR4-NOT transcription complex, subunit 3-HPRD,BioGRID10637334 
CNOT4CLONE243 | NOT4 | NOT4HCCR4-NOT transcription complex, subunit 4-HPRD10637334 
CNOT6CCR4 | KIAA1194CCR4-NOT transcription complex, subunit 6-HPRD10637334 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_RNA_DEGRADATION 5937All SZGR genes in this pathway
REACTOME_DEADENYLATION_OF_MRNA 2214All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 4829All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN 6642All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN 384220All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
SEIDEN_MET_SIGNALING 1916All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
CHEOK_RESPONSE_TO_HD_MTX_DN 2418All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70 6733All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1382592661A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-200bc/429126612721Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-7209215m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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