Gene Page: KL

Summary
GeneID  9365
Symbol  KL
Synonyms  -
Description  klotho
See related  HGNC:6344|MIM:604824|Ensembl:ENSG00000133116|HPRD:05316|
Locus tag  -
Gene type  protein-coding
Map location  13q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0004871signal transducer activityTAS9363890 
GO:0005499vitamin D bindingIEA-
GO:0004566beta-glucuronidase activityIEA-
GO:0008422beta-glucosidase activityTAS9363890 
GO:0043169cation bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006112energy reserve metabolic processIEA-
GO:0005975carbohydrate metabolic processIEA-
GO:0008543fibroblast growth factor receptor signaling pathwayEXP17086194 
GO:0008152metabolic processIEA-
GO:0007568agingIMP11792841 
GO:0030501positive regulation of bone mineralizationIMP12110410 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP17086194 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS9464267 
GO:0005624membrane fractionTAS9464267 
GO:0005625soluble fractionTAS9464267 
GO:0005886plasma membraneEXP17086194 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9464267 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE 3627All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 5440All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_CASCADE 2819All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION 2215All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
SU_KIDNEY 158All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_POOR_SURVIVAL_UP 3122All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME2 1711All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1013481354m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-199106210691A,m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-330112911351Ahsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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