Gene Page: PICK1

Summary
GeneID  9463
Symbol  PICK1
Synonyms  MGC15204|PICK|PRKCABP
Description  protein interacting with PRKCA 1
See related  HGNC:9394|MIM:605926|Ensembl:ENSG00000100151|HPRD:16176|
Locus tag  RP5-1039K5.11
Gene type  protein-coding
Map location  22q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.7105 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CPNE60.600.68
NELF0.580.65
PRKCG0.570.68
CD60.570.57
CNGB10.570.60
FIBCD10.560.50
SUSD40.560.61
SYT170.550.62
GALNTL40.540.53
TTC7B0.540.66
Top 10 negatively co-expressed genes
KIAA1949-0.27-0.22
RBMX2-0.26-0.39
ZNF193-0.25-0.18
FAM167B-0.25-0.39
TUBB2B-0.25-0.26
SH2B2-0.25-0.34
AP000349.1-0.25-0.27
SPATA9-0.25-0.26
TMSB15A-0.25-0.28
ZNF300-0.25-0.13
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingISSNeurotransmitter (GO term level: 4)-
GO:0005080protein kinase C bindingISS-
GO:0008022protein C-terminus bindingIPI11343649 
GO:0016887ATPase activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045161neuronal ion channel clusteringTASneuron (GO term level: 11)11343649 
GO:0007205activation of protein kinase C activityIDA10623590 
GO:0006468protein amino acid phosphorylationISS-
GO:0006605protein targetingIEA-
GO:0006890retrograde vesicle-mediated transport, Golgi to ERNAS10623590 
GO:0015844monoamine transportIDA11343649 
GO:0043046DNA methylation during gametogenesisTAS12138111 
GO:0043113receptor clusteringISS-
GO:0043045DNA methylation during embryonic developmentNAS12138111 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042734presynaptic membraneIDAneuron, axon, Synap (GO term level: 5)11343649 
GO:0045202synapseISSneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005794Golgi apparatusISS-
GO:0005737cytoplasmIDA11343649 
GO:0005739mitochondrionIEA-
GO:0005886plasma membraneIDA11343649 
GO:0048471perinuclear region of cytoplasmISS-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACCN1ACCN | ASIC2 | ASIC2a | BNC1 | BNaC1 | MDEG | hBNaC1amiloride-sensitive cation channel 1, neuronalPICK1 interacts with BNC1a.BIND11802773 
-HPRD11739374 
PICK1 interacts with BNC1b.BIND11802773 
ACCN2ASIC | ASIC1 | ASIC1A | BNaC2 | hBNaC2amiloride-sensitive cation channel 2, neuronalPICK1 interacts with ASIC.BIND11802773 
-HPRD,BioGRID11739374 |11802773 
|12578970 
BNC1BNC | BSN1 | HsT19447basonuclin 1Affinity Capture-Western
Two-hybrid		BioGRID11802773 
BTG2MGC126063 | MGC126064 | PC3 | TIS21BTG family, member 2-HPRD11237868 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1-HPRD,BioGRID9883737 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID11278603 
ERBB2IPERBIN | LAP2erbb2 interacting proteinTwo-hybridBioGRID11278603 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1-HPRD,BioGRID11891216 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Reconstituted Complex
Two-hybrid		BioGRID11891216 
GRIA3GLUR-C | GLUR-K3 | GLUR3 | GLURC | MRX94glutamate receptor, ionotrophic, AMPA 3Reconstituted Complex
Two-hybrid		BioGRID11891216 
GRIA4GLUR4 | GLUR4C | GLURDglutamate receptor, ionotrophic, AMPA 4Reconstituted Complex
Two-hybrid		BioGRID11891216 
GRIK1EAA3 | EEA3 | GLR5 | GLUR5glutamate receptor, ionotropic, kainate 1-HPRD11891216 
-HPRD,BioGRID12597860 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD,BioGRID12597860 
GRIK3EAA5 | GLR7 | GLUR7 | GluR7aglutamate receptor, ionotropic, kainate 3Reconstituted Complex
Two-hybrid		BioGRID11891216 
GRM3GLUR3 | GPRC1C | MGLUR3 | mGlu3glutamate receptor, metabotropic 3Reconstituted Complex
Two-hybrid		BioGRID11891216 
GRM7FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7glutamate receptor, metabotropic 7PICK1 interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between PICK1 from an unspecified species and human mGluR7b.BIND11891216 
Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID11007882 
LRP2BPDKFZp761O0113 | FLJ44965LRP2 binding protein-HPRD12508107 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1PICK1 interacts with another PICK1.BIND11802773 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaAffinity Capture-WesternBioGRID11007882 
PRLHRGPR10 | GR3 | MGC126539 | MGC126541 | PrRPRprolactin releasing hormone receptorAffinity Capture-WesternBioGRID11641419 
SLC6A3DAT | DAT1solute carrier family 6 (neurotransmitter transporter, dopamine), member 3-HPRD,BioGRID11343649 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 1611All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_UP 14293All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_UP 4224All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_UP 9258All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP 6941All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_CANCER_UP 3123All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN 6845All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN 8053All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-21496102m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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