Gene Page: ATG5

Summary
GeneID  9474
Symbol  ATG5
Synonyms  APG5|APG5-LIKE|APG5L|ASP|hAPG5
Description  ATG5 autophagy related 5 homolog (S. cerevisiae)
See related  HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|
Locus tag  -
Gene type  protein-coding
Map location  6q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.799 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TUBB0.950.72
MARCKSL10.950.83
HN10.940.73
PAFAH1B30.940.81
C6orf1340.930.71
IGFBP20.930.80
EIF4A10.930.73
TUBB2B0.930.88
TUBB30.930.71
DBN10.930.71
Top 10 negatively co-expressed genes
FBXO2-0.70-0.68
C5orf53-0.69-0.67
HLA-F-0.68-0.63
CCNI2-0.67-0.73
AF347015.27-0.66-0.72
LDHD-0.65-0.61
AIFM3-0.65-0.57
ALDOC-0.65-0.59
GBP2-0.64-0.73
RGS5-0.64-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI9852036 |11096062 
GO:0005515protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000045autophagic vacuole formationISS-
GO:0006915apoptosisIEA-
GO:0006914autophagyIEA-
GO:0006914autophagyISS-
GO:0043687post-translational protein modificationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005737cytoplasmISS-
GO:0005776autophagic vacuoleIDA15292400 
GO:0043231intracellular membrane-bounded organelleISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATG10APG10 | APG10L | DKFZp586I0418 | FLJ13954 | pp12616ATG10 autophagy related 10 homolog (S. cerevisiae)-HPRD12482611 
ATG12APG12 | APG12L | FBR93 | HAPG12ATG12 autophagy related 12 homolog (S. cerevisiae)-HPRD11825910 |12482611 
Affinity Capture-MSBioGRID17353931 
ATG16L1APG16L | ATG16L | FLJ00045 | FLJ10035 | FLJ10828 | FLJ22677 | IBD10 | WDR30ATG16 autophagy related 16-like 1 (S. cerevisiae)-HPRD12665549 
IMPDH2IMPD2 | IMPDH-IIIMP (inosine monophosphate) dehydrogenase 2Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_REGULATION_OF_AUTOPHAGY 3530All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING 3119All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 7357All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN 14591All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
WENDT_COHESIN_TARGETS_UP 3319All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
MIZUSHIMA_AUTOPHAGOSOME_FORMATION 1915All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1535465521Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-18112711277m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-299-5p492498m8hsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-30-5p5255321A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-4485465521Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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