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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NCOR2

Summary

GeneID

9612

Symbol

NCOR2

Synonyms

Description

nuclear receptor co-repressor 2

Locus tag

Gene type

protein-coding

Map location

12q24

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

IEA

GO:0003677

DNA binding

IEA

GO:0003714

transcription corepressor activity

TAS

7566127

GO:0005112

Notch binding

IPI

10713164

GO:0005515

protein binding

IPI

10713164 |15016912

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0045449

regulation of transcription

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

TAS

10097068

GO:0005730

nucleolus

IDA

18029348

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western Co-localization Reconstituted Complex Two-hybrid	BioGRID	11923464 \|12441355 \|14593076
BCL6	BCL5 \| BCL6A \| LAZ3 \| ZBTB27 \| ZNF51	B-cell CLL/lymphoma 6	-	HPRD,BioGRID	9765306
BCL6	BCL5 \| BCL6A \| LAZ3 \| ZBTB27 \| ZNF51	B-cell CLL/lymphoma 6	The lateral groove motif in the BTB domain of BCL6 interacts with the BBD motif of SMRT.	BIND	15531890
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	The cIAP-2 promoter interacts with SMRT.	BIND	15494311
CBFA2T2	DKFZp313F2116 \| EHT \| MTGR1 \| ZMYND3	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	-	HPRD	12242670
CCL3	G0S19-1 \| LD78ALPHA \| MIP-1-alpha \| MIP1A \| SCYA3	chemokine (C-C motif) ligand 3	SMRT interacts with the CCL3 promoter region.	BIND	15531890
CCND2	KIAK0002 \| MGC102758	cyclin D2	SMRT interacts with the CCND2 promoter region.	BIND	15531890
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	NCOR2 (SMRT) interacts with p-p14(ARF) (p14(ARF) promoter).	BIND	15729358
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	IKK-alpha phosphorylates SMRT.	BIND	15494311
CIR	-	CBF1 interacting corepressor	-	HPRD,BioGRID	11509665
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	ESR1 (ER-alpha) interacts with NCOR2 (SMRT). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and NCOR2 from an unspecified species.	BIND	12738788
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD	9702189
FOS	AP-1 \| C-FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	-	HPRD,BioGRID	10777532
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	Affinity Capture-Western Co-purification	BioGRID	11013263 \|11739383
HDAC10	DKFZp761B039 \| MGC149722	histone deacetylase 10	-	HPRD,BioGRID	11739383
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Co-purification	BioGRID	11013263
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	Affinity Capture-MS Affinity Capture-Western Co-fractionation Co-purification Reconstituted Complex	BioGRID	10809664 \|10944117 \|11013263 \|11804585 \|12502735 \|12628926 \|14527417
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	-	HPRD,BioGRID	11804585
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	-	HPRD	10869435
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	Reconstituted Complex Two-hybrid	BioGRID	10640275
HDAC7	DKFZp586J0917 \| FLJ99588 \| HD7A \| HDAC7A	histone deacetylase 7	Affinity Capture-Western	BioGRID	11466315
IKZF1	Hs.54452 \| IK1 \| IKAROS \| LYF1 \| PRO0758 \| ZNFN1A1 \| hIk-1	IKAROS family zinc finger 1 (Ikaros)	Affinity Capture-Western	BioGRID	11959865
IL8	CXCL8 \| GCP-1 \| GCP1 \| LECT \| LUCT \| LYNAP \| MDNCF \| MONAP \| NAF \| NAP-1 \| NAP1	interleukin 8	The IL-8 promoter interacts with SMRT.	BIND	15494311
INPP5K	PPS \| SKIP	inositol polyphosphate-5-phosphatase K	Two-hybrid	BioGRID	11509665
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	Reconstituted Complex Two-hybrid	BioGRID	10777532
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	-	HPRD	11997503
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD	10406466
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	-	HPRD	9267036
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	Co-fractionation	BioGRID	10944117
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD	10777532
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Affinity Capture-Western	BioGRID	12589049
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	12011091
NR4A1	GFRP1 \| HMR \| MGC9485 \| N10 \| NAK-1 \| NGFIB \| NP10 \| NUR77 \| TR3	nuclear receptor subfamily 4, group A, member 1	-	HPRD,BioGRID	11559707
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	11585900
POU2F1	OCT1 \| OTF1	POU class 2 homeobox 1	-	HPRD,BioGRID	11134019
PPARA	MGC2237 \| MGC2452 \| NR1C1 \| PPAR \| hPPAR	peroxisome proliferator-activated receptor alpha	-	HPRD,BioGRID	11845213
PPARD	FAAR \| MGC3931 \| NR1C2 \| NUC1 \| NUCI \| NUCII \| PPAR-beta \| PPARB	peroxisome proliferator-activated receptor delta	-	HPRD,BioGRID	11867749
PPARD		peroxisome proliferator-activated receptor delta	PPAR-delta interacts with SMRT. This interaction was modelled on a demonstrated interaction between PPAR-delta and SMRT from unspecified sources.	BIND	12970571
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	Affinity Capture-Western Reconstituted Complex	BioGRID	9256429 \|11929748
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	NCOR2 (SMRT) interacts with p-RAR-alpha2 (RAR-alpha2 promoter).	BIND	15729358
RBPJ	CBF1 \| IGKJRB \| IGKJRB1 \| KBF2 \| MGC61669 \| RBP-J \| RBPJK \| RBPSUH \| SUH \| csl	recombination signal binding protein for immunoglobulin kappa J region	-	HPRD,BioGRID	11509665
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	12589049
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	-	HPRD,BioGRID	11113190
SAP30	-	Sin3A-associated protein, 30kDa	-	HPRD	9702189
SAP30	-	Sin3A-associated protein, 30kDa	Co-purification	BioGRID	11013263
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Co-fractionation Reconstituted Complex	BioGRID	10640275 \|10944117
SIRT1	SIR2L1	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)	Sirt1 interacts with SMRT.	BIND	15175761
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Co-fractionation	BioGRID	10944117
SNW1	Bx42 \| MGC119379 \| NCOA-62 \| PRPF45 \| Prp45 \| SKIIP \| SKIP	SNW domain containing 1	Affinity Capture-Western in vitro in vivo Two-hybrid	BioGRID	10644367 \|10713164
SNW1	Bx42 \| MGC119379 \| NCOA-62 \| PRPF45 \| Prp45 \| SKIIP \| SKIP	SNW domain containing 1	-	HPRD	10713164 \|11509665
SPEN	KIAA0929 \| MINT \| RP1-134O19.1 \| SHARP	spen homolog, transcriptional regulator (Drosophila)	-	HPRD,BioGRID	11331609
SRF	MCM1	serum response factor (c-fos serum response element-binding transcription factor)	-	HPRD,BioGRID	10777532
STAT5A	MGF \| STAT5	signal transducer and activator of transcription 5A	-	HPRD	11726519
STAT5B	STAT5	signal transducer and activator of transcription 5B	-	HPRD	11726519
TBL1X	EBI \| SMAP55 \| TBL1	transducin (beta)-like 1X-linked	-	HPRD,BioGRID	10809664
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Reconstituted Complex	BioGRID	9751500
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	Reconstituted Complex	BioGRID	12460926
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	14-3-3-epsilon interacts with SMRT.	BIND	15494311
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	-	HPRD	9256429 \|14982881
			Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9256429 \|9765306 \|14982881
			SMRT interacts with PLZF. This interaction was modelled on a demonstrated interaction between SMRT and PLZF from unspecified species.	BIND	9486654

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_NOTCH_SIGNALING_PATHWAY	47	35	All SZGR genes in this pathway
BIOCARTA_CARM_ER_PATHWAY	35	27	All SZGR genes in this pathway
BIOCARTA_EGFR_SMRTE_PATHWAY	11	11	All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY	58	43	All SZGR genes in this pathway
BIOCARTA_ETS_PATHWAY	18	12	All SZGR genes in this pathway
BIOCARTA_RARRXR_PATHWAY	15	9	All SZGR genes in this pathway
PID_NOTCH_PATHWAY	59	49	All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY	34	27	All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY	66	50	All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY	26	24	All SZGR genes in this pathway
PID_ERA_GENOMIC_PATHWAY	65	37	All SZGR genes in this pathway
PID_RETINOIC_ACID_PATHWAY	30	23	All SZGR genes in this pathway
PID_HES_HEY_PATHWAY	48	39	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	46	28	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1	70	46	All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	38	26	All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY	20	14	All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	352	181	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS	478	302	All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM	168	115	All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	72	53	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH	103	64	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	63	42	All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP	201	125	All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN	493	298	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP	485	293	All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP	95	64	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN	536	332	All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN	329	219	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN	508	354	All SZGR genes in this pathway
SCHEIDEREIT_IKK_TARGETS	18	15	All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC	44	31	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC	108	74	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	483	336	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN	637	377	All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN	98	59	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN	428	306	All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	151	100	All SZGR genes in this pathway
KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP	51	29	All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES	244	154	All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP	77	52	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN	50	32	All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN	52	33	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C5	46	36	All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1	419	273	All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP	566	371	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP	439	257	All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES	389	245	All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION	456	287	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP	211	131	All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP	281	183	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	670	677	1A,m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	670	677	1A,m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-124.1	169	175	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-125/351	215	221	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	215	221	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-184	136	143	1A,m8	hsa-miR-184	UGGACGGAGAACUGAUAAGGGU
miR-29	232	238	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-5p	224	230	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-331	217	223	1A	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-9	377	383	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.