Gene Page: PPM1F

Summary
GeneID  9647
Symbol  PPM1F
Synonyms  CaMKPase|FEM-2|KIAA0015|POPX2|hFEM-2
Description  protein phosphatase 1F (PP2C domain containing)
See related  HGNC:19388|Ensembl:ENSG00000100034|HPRD:10163|
Locus tag  -
Gene type  protein-coding
Map location  22q11.22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EIF4B0.930.92
IGBP10.920.88
INTS70.910.92
COMMD20.910.89
ARG20.900.91
KARS0.900.92
CCT30.900.89
POLR1E0.900.90
EEF20.900.89
TEX100.900.91
Top 10 negatively co-expressed genes
MT-CO2-0.65-0.86
AF347015.31-0.65-0.85
AF347015.33-0.65-0.85
FXYD1-0.64-0.87
C5orf53-0.64-0.77
HLA-F-0.63-0.78
AF347015.27-0.63-0.84
IFI27-0.63-0.85
HEPN1-0.63-0.77
MT-CYB-0.63-0.83
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0004722protein serine/threonine phosphatase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0030145manganese ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006470protein amino acid dephosphorylationIEA-
GO:0006915apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0008287protein serine/threonine phosphatase complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF7BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXBRho guanine nucleotide exchange factor (GEF) 7-HPRD,BioGRID11864573 
FAM161AFLJ13305 | MGC129982 | MGC129983family with sequence similarity 161, member ATwo-hybridBioGRID16169070 
FEM1ADKFZp762M136 | EPRAPfem-1 homolog a (C. elegans)-HPRD11559703 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD11864573 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN 7746All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
PATTERSON_DOCETAXEL_RESISTANCE 2920All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_UP 8648All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
GEORGANTAS_HSC_MARKERS 7147All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP 3826All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_UP 4729All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_CISPLATIN 2014All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
CERIBELLI_GENES_INACTIVE_AND_BOUND_BY_NFY 4527All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1942948m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5069419481A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-14919441950m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-200bc/429719725m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2178648701Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-299-5p365036561Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-34227532759m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-37727522758m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-96750756m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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