Gene Page: MDC1

Summary
GeneID  9656
Symbol  MDC1
Synonyms  DKFZp781A0122|KIAA0170|MGC166888|NFBD1
Description  mediator of DNA damage checkpoint 1
See related  HGNC:21163|MIM:607593|Ensembl:ENSG00000137337|HPRD:16252|
Locus tag  DAAP-285E11.7
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12607005 |17525332 |18001824 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006281DNA repairIEA-
GO:0007049cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIDA18029348 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA15604234 
GO:0005654nucleoplasmEXP12556884 |12607003 
GO:0005925focal adhesionIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutated-HPRD12607005 
Affinity Capture-WesternBioGRID14519663 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD12607005 
Affinity Capture-WesternBioGRID17525332 
CENPC1CENP-C | CENPC | MIF2 | hcp-4centromere protein C 1Protein-peptideBioGRID14578343 
CHEK2CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53CHK2 checkpoint homolog (S. pombe)-HPRD,BioGRID12551934 |12607004 
GATA4MGC126629GATA binding protein 4Protein-peptideBioGRID14578343 
H2AFXH2A.X | H2A/X | H2AXH2A histone family, member X-HPRD,BioGRID12607005 |14519663 
HDAC10DKFZp761B039 | MGC149722histone deacetylase 10Protein-peptideBioGRID14578343 
HDAC8HDACL1 | RPD3histone deacetylase 8Protein-peptideBioGRID14578343 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)Protein-peptideBioGRID14578343 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)Affinity Capture-MS
Affinity Capture-Western		BioGRID14519663 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrin-HPRD,BioGRID12607003 |12607005 
|14519663 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaProtein-peptideBioGRID14578343 
RAD50RAD50-2 | hRad50RAD50 homolog (S. cerevisiae)Affinity Capture-WesternBioGRID14519663 
SMC1ACDLS2 | DKFZp686L19178 | DXS423E | KIAA0178 | MGC138332 | SB1.8 | SMC1 | SMC1L1 | SMC1alpha | SMCBstructural maintenance of chromosomes 1A-HPRD12607005 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID14519663 
TP53BP153BP1 | FLJ41424 | MGC138366 | p202tumor protein p53 binding protein 1-HPRD12607005 
WRNDKFZp686C2056 | RECQ3 | RECQL2 | RECQL3Werner syndromeProtein-peptideBioGRID14578343 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ATM_PATHWAY 3425All SZGR genes in this pathway
REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 1711All SZGR genes in this pathway
REACTOME_DOUBLE_STRAND_BREAK_REPAIR 2414All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_DN 12267All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
COLLIS_PRKDC_REGULATORS 1510All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
CROMER_METASTASIS_UP 7946All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_UP 13484All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR 12873All SZGR genes in this pathway


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