| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1017 |
Name | CDK2 |
Synonym | CDKN2|p33(CDK2);cyclin-dependent kinase 2;CDK2;cyclin-dependent kinase 2 |
Definition | cdc2-related protein kinase|cell division protein kinase 2|p33 protein kinase |
Position | 12q13 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 1444 |
TUSON P-value | 0.089608075 |
|
Pathways and Diseases |
|
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | DNA Replication;Reactome;REACT:383 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | p53-Dependent G1 DNA Damage Response;PID Reactome;500315 |
Pathway | cdk regulation of dna replication;PID BioCarta;100110 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | SCF(Skp2)-mediated degradation of p27/p21;PID Reactome;500372 |
Pathway | Signaling events mediated by PRL;PID Curated;200006 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | e2f1 destruction pathway;PID BioCarta;100034 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | G2 Phase;PID Reactome;500986 |
Pathway | Activation of the pre-replicative complex;PID Reactome;500981 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Cyclin A:Cdk2-associated events at S phase entry;PID Reactome;500375 |
Pathway | rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046 |
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Cyclin E associated events during G1/S transition;PID Reactome;500877 |
Pathway | p53 signaling pathway;PID BioCarta;100083 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | cyclin e destruction pathway;PID BioCarta;100166 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | cyclins and cell cycle regulation;PID BioCarta;100207 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | Regulation of APC/C activators between G1/S and early anaphase;PID Reactome;500391 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | CDK-mediated phosphorylation and removal of Cdc6;PID Reactome;500925 |
Pathway | regulation of p27 phosphorylation during cell cycle progression;PID BioCarta;100087 |
Disease | type 1 diabetes;GAD |
Disease | IMMUNE;GAD |
|
External Links |
|
Links to Entrez Gene | 1017 |
Links to all GeneRIF Items | 1017 |
Links to iHOP | 1017 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1017 : length: 897 atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa gccagaaacaagttgacgggagaggtggtggcgcttaagaaaatccgcctggacactgag actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattat tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga |
Protein Sequence |
>1017 : length: 298 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL |